Hypoallergenic allergy vaccines based on the timothy grass...

Details Hypoallergenic allergy vaccines based on the timothy grass... Hypoallergenic allergy vaccines based on the timothy grass...

2003-09-25

2008-09-16

Haddad, Maher M. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S275100, C514S002600, C530S300000

Reexamination Certificate

active

07425333

ABSTRACT:
The present invention pertains to polypeptides derived from the timothy grass pollen allergen Phl p 7. The polypeptides display reduced allergen activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccination.

REFERENCES:
patent: WO 99/34826 (1999-07-01), None
patent: WO-1999/34826 (1999-07-01), None
patent: WO 99/38978 (1999-08-01), None
Fatima Ferreira et al., “Modulation of IgE reactivity of allergens by site-directed mutagesis: potential use of hypoallergenic variants for immunotherapy”, The FASEB Journal, Feb. 1998, pp. 231-242, vol. 12.
Verena Niederberger et al., “Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p7”, The FASEB Journal, May 1999, pp. 843-856, vol. 13.
Cenk Suphioglu et al, “Molecular cloning and immunological characterization of Cyn d 7, a novel calcium-binding allergen from Bermuda grass pollen”, FEBS Letters, 1997, pp. 167-172, vol. 402.
Susanne Vrtala et al., “Conversion pf the Major Birch Pollen Allergen, Bet v 1, into Two Nonanaphylactic T Cell Epitope-containing Fragments”, Journal of Clinical Investigation, 1997, pp. 1673-1681, Vo. 99, No. 7.

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