Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-02-24
1990-03-13
Stone, Jacqueline M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 23, 514 59, 514 60, 514921, 424680, A61K 3702, A61K 3314, A61K 3170
Patent
active
049083503
ABSTRACT:
A physiologically acceptable solution which is both hyperosmotic and hyperoncotic with respect to blood plasma and has utility in treating patients experiencing or threatening to experience hypodynamic shock. The physiologically acceptable solution comprises a hyperosmotic concentration of a crystalloid (in excess of about 1800 mOsms) and hyperoncotic concentration of a colloid (in excess of about 30 mm Hg). The physiologically acceptable solution is easily administered by single, rapid infusion of approximately 4 to 5 ml/kg of body weight and results in a rapid and sustained normalization of circulatory function.
REFERENCES:
patent: 3864478 (1975-02-01), Bonhard
patent: 3993750 (1976-11-01), Fox, Jr.
patent: 4049795 (1977-09-01), Laborit
patent: 4271144 (1981-06-01), Holly
patent: 4308255 (1981-12-01), Raj et al.
Modig, Biol. Abstracts 78(3): 21473 No. 2745 1983.
Pristoupil, Chem. Abstracts vol. 82, 1975, No. 47728b.
Hyperosmotic NaCl and Severe Hemorrhagic Shock by I. T. Velasco, V. Pontieri, M. Rocha E. Silva, Jr. and O. U. Lopes, pp. H664-673 1980 (Heart Circ. Physiol. 8).
Hyperosmotic NaCl and Severe Hemorrhagic Shock: Role of the Innervated Lung, O. U. Lopes, V. Pontieri, M. Rocha E. Silva, Jr., and I. T. Velasco (Am. J. Physiol 241) (Heart Circ. Physiol. 20: H883-H890) 1981.
Body Fluid Changes During Hypertonic Lactated Saline Solution Therapy for Burn Shock, Shuji Shimazaki, M.D. et al., The Journal of Trauma, vol. 17, pp. 38-43 (1977).
Treatment of Experimental Shock; Comparison of the Effects of Non-epinephrine, Dibenzyline, Dextran, Whole Blood, and Balanced Saline Solutions, R. F. Rush, Jr., M.D., Surgery vol. 61, No. 6, pp. 938-944 (1967).
Comparison of Isotonic and Hypertonic Solutions and Blood Flow and Oxygen Consumption in the Initial Treatment of Hemorrhagic Shock, Arthur E. Baue, M.D. et al., J. of Trauma, vol. 7, No. 5, pp. 743-756 (1967).
Lopes et al., Chemical Abstracts vol. 96:617p (1982).
Velasco et al., Chemical Abstracts vol. 93:215562r (1980).
Silbert, Samuel. The treatment of thromboangiitis obliterans. Journal A.M.A. 1759-1761 (Jun. 5, 1926).
Fraser, John; Cowell, E. M. Clinical Study of Blood Pressure in Wound Conditions. Journal A.M.A. Feb. 23, 1918.
Danowski, T. S.; Winkler, A. W.; Elkinton, J. T. The Treatment of Shock Due to Salt Depletion; Comparison of the Hemodynamic Effects of Isotonic Saline, of Hypertonic Saline, and of Isotonic Glucose Solutions. J.C.I. 215:130-138 (1946).
Rush, R. F. Jr. Treatment of Experimental Shock: Comparison of the Effects of Nonepinephrine, Dibenzyline, Dextran, Whole Blood, and Balance Saline Solutions. Surgery, vol. 61, No. 6, 938-944. 1967.
Brooks, D. K.; Williams; W. G.; Morley, R. W.; Whiteman, R. Osmolar and Electrolyte Changes in Haemorrhagic Shock. The Lancet. pp. 521,527, Mar. 9, 1963.
Holcroft James W.
Kramer George C.
Stone Jacqueline M.
The Regents of the University of California
LandOfFree
Hyperosmotic/hyperoncotic solutions for resuscitation of hypodyn does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hyperosmotic/hyperoncotic solutions for resuscitation of hypodyn, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hyperosmotic/hyperoncotic solutions for resuscitation of hypodyn will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-51289