Hydroxamic acid-containing inhibitors of matrix metalloproteases

Details Hydroxamic acid-containing inhibitors of matrix metalloproteases Hydroxamic acid-containing inhibitors of matrix metalloproteases

1994-12-29

1997-06-17

Conrad, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514277, 514359, 514507, 546341, 548535, 560 41, 560 49, 562623, A61K 31215, C07D20700, C07C22900

Patent

active

056397461

ABSTRACT:
The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula I ##STR1## wherein (A)R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently selected from various substituents; and

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