Hydroxamic acid and carboxylic acid derivatives, process for the

Details Hydroxamic acid and carboxylic acid derivatives, process for the Hydroxamic acid and carboxylic acid derivatives, process for the

1994-02-25

1996-05-07

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

560 34, 560 35, 560 37, 560 38, 560 39, 560 40, 560 41, 560 42, 560168, 560169, 562437, 562439, 562442, 562445, 562448, 562450, 564448, 564450, 564165, 564164, 564168, 564169, 564170, 564193, 564199, 564201, A61K 31195

Patent

active

055147160

ABSTRACT:
This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of matrix metalloproteinase induced diseases.

REFERENCES:
patent: 4091024 (1978-05-01), Ondetti
patent: 5304549 (1994-04-01), Broadhurst et al.
Roques et al, Chem. Abst., vol. 115, #136,778K (1991).
Isomura et al, Chem. Abst., vol., 114, #181,227y (1993).
Ondetti, Chem. Abst., vol. 90, #6699q (1979).

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