Hydrophilic binary systems for the administration of lipophilic

Details Hydrophilic binary systems for the administration of lipophilic Hydrophilic binary systems for the administration of lipophilic

1998-03-12

1999-12-28

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514885, 514975, A61K 910, A61K 950, A61K 4734

Patent

active

060081929

ABSTRACT:
Binary pharmaceutical compositions comprising (i) a cyclosporine compound, (ii) a hydrophilic phase and (iii) a surfactant provide bioavailability of the active ingredient which is equivalent to that provided by ternary compositions, but without the need for a lipophilic phase.

REFERENCES:
patent: 4117118 (1978-09-01), Harri et al.
patent: 4388307 (1983-06-01), Cavanak
patent: 5342625 (1994-08-01), Hauer et al.
patent: 5614491 (1997-03-01), Walch et al.
patent: 5766629 (1998-01-01), Cho et al.
Derwent Abstract 89-088668, "Drugs of Soluble Cyolosporin Powder"Feb, 1989.
S.A. Charman et al., "Self-Emusifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound, " Pharmaceutical Research, 9 (1): 87-93 (1992).
N.H. Shah et al., "Self-Emusifying Drug Delivery Systems (SEEDS) With Polyglycolyzed Glycerides For Improving In Vitro Dissolution and Oral Absorption of Lipophilic Drugs, " International Journal Of Pharmaceutics, 106: 15-23 (1994).

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