Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Cellular products or processes of preparing a cellular...
Reexamination Certificate
2005-11-01
2005-11-01
Seidleck, James J. (Department: 1711)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Cellular products or processes of preparing a cellular...
C521S109100, C521S142000, C521S146000, C521S149000, C521S182000, C521S183000, C521S186000, C521S187000, C521S084100
Reexamination Certificate
active
06960617
ABSTRACT:
Hydrogels having improved elasticity and mechanical strength properties are obtained by subjecting a hydrogel formulation containing a strengthening agent to chemical or physical crosslinking conditions subsequent to initial gel formation. Superporous hydrogels having improved elasticity and mechanical strength properties are similarly obtained whenever the hydrogel formulation is provided with a foaming agent. Interpenetrating networks of polymer chains comprised of primary polymer(s) and strengthening polymer(s) are thereby formed. The primary polymer affords capillary-based water sorption properties while the strengthening polymer imparts significantly enhanced mechanical strength and elasticity to the hydrogel or superporous hydrogel. Suitable strengthening agents can be natural or synthetic polymers, polyelectrolytes, or neutral, hydrophilic polymers.
REFERENCES:
patent: 4421824 (1983-12-01), Gupta et al.
patent: 4814179 (1989-03-01), Bolton et al.
patent: 5232704 (1993-08-01), Franz et al.
patent: 5264082 (1993-11-01), Phan et al.
patent: 5718916 (1998-02-01), Scherr
patent: 5750585 (1998-05-01), Park et al.
patent: 6143132 (2000-11-01), Traubel et al.
patent: 6271278 (2001-08-01), Park et al.
Park H., and Park K.: Hydrogel foams: A new type of fast swelling hydrogels Transactions of Society of Biomaterials 17: 158, 1994.
Chen J., Park H., and Park K.: Synthesis of superporous hydrogels: Hydrogels with fast swelling and superabsorbent properties, Journal of Biomedical Materials Research 44:53-62. 1999.
Patel V.R., A.M.M.: Preparation and characterization of freeze-dried chitosan—poly(ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach, Pharmaceutical Research 13: 588-593, 1996.
Oxley H.R., Corkhill P.H., Fitton J.H., and Tighe B.J.: Macroporous hydrogels for biomedical applications: Methods and morphology, Biomaterials 14: 1064-1072, 1993.
Kon M., d.V.A.C.: A poly(hema) sponge for restoration of articular cartilage defects, Plastic and Reconstructive Surgery 67:288-294, 1981.
Badiger M.V., McNeil M.E., and Graham N.B.: Progens in the preparation of microporous hydrogels based on poly(ethylene oxide), Biomaterials 14: 1059-1063, 1993.
Bennett D.J., Burford R.P., Davis T.P., and Tilley H.J.: Synthesis of porous hydrogel structure by polymerizing the continuous phase of a microemulsion, Polymer International 36: 219-226. 1995.
Chirila T.V., Constable I.J., Crowford J., Vijaysekaran S., Thompson D.E., Chen Y.C., and Fletcher W.A.: Poly(2-hydroxyethyl methacrylate) sponges as implant materials: In vivo and in vitro evaluation of celluar invasion, Biomaterials 14, 26-36: 1994.
Khemani K.C: Polymeric foams: Science and technology, ACS Symposium Series, American Chemical Society, Washington DC 239: 1997.
Klempner D., and Frisch K.C.: Handbook of polymeric foams and foam technology, Hanser Publishers, Munich, 1991.
Spaans C.J.: Solvent-free fabrication of micro-porous polyurethane amide and polyurethane-urea scaffolds for repair and replacement of the knee-joint meniscus, Biomaterials 21: 2453-2460, 2000.
Elema H., deGroot J. H., and Nijenhuis A.J.: Use of porous biodegradable polymer implants in meniscus reconstruction. 2)biological evaluation of porous biodegradable polymer implants in menisci, Colloid Polymer Science 268: 1082-88, 1990.
de Groot J.H.: Use of porous biodegradable polymer implants in meniscus reconstruction. 1)preparation of porous biodegradable polyurethanes for the reconstruction of the meniscus, Colloid Polymer Science 268: 1073-81, 1990.
de Groot J. H., Zijlstra F. M., and Kuijpers H. W.: Meniscal tissue regeneration in porous 50/50 copoly(l-lactide/caprolactone) implants, Biomaterials 18: 613-22, 1997.
Kim B.S., and Mooney D. J.: Development of biocompatible synthetic extracellular matrices for tissue engineering, TIBTECH 16: 224-230, 1998.
Griffith L. G.: Polymeric biomaterials, Acta Materialia 48: 263-277, 2000.
Kang H. W., Tabata Y., and Ikada Y.: Fabrication of porous gelatin scaffolds for tissue engineering, Biomaterials 20: 1339-1344, 1999.
Bryant S. J., and Anseth K. S.: The effect of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels, Biomaterials 22: 619-626, 2001.
Park K., and Omidian H.: Experimental design in the synthesis of polyacrylamide superporous hydrogels, J. of Bioactive and Compatible Polymers, vol. 17(6), 2002.
Glicksman M.: Gum technology in the food industry, Academic Press, 163, 1969.
Gombotz W. R., and Wee SF.: Protein release from alginate matrices, Advanced Drug Delivery Reviews 31: 267-285, 1998.
Kuo C.K., and M P. X.: Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties, Biomaterials 22: 511-521, 2001.
Eiselt P., Yeh J., Latvala R. K., Shea L.D., and Mooney D. J.: Porous carriers for biomedical applications based on alginate hydrogels, Biomaterials 21: 1921-1927, 2000.
Shapiro L., and Cohen S.: Novel alginate sponges for cell culture and transplantation, Biomaterials 18: 583-590, 1997.
Vorlop K. D., Steinert H. J., and Klein J.: Cell immobilization within coated alginate beads or hollow fibers by ionotropic gelation, Annals of the New York Academy of Sciences 501: 339-342, 1987.
Hills B. P., Godward J., Debatty M., Barras L., Saturio C. P., and Ouwerx C.: Nmr studies of calcium induced alginate gelation. Part ii. The internal bead structure, Magnetic Resonance in Chemistry 38 719-728, 2000.
Duez J. M., Mestdagh M., Demeure R., Goudemant J. F., Hills B. P., and Godward J.: Nmr studies of calcium-induced alginate gelation. Part 1-mri tests of gelation models, Magnetic Resonance in Chemistry 38: 324-330, 2000.
LeRoux M. A., Guilak F., and Setton L. A.: Compressive and shear properties of alginate gel: Effects of sodium ions and alginate concentration, Journal of Biomedical Materials Research 47: 46-53, 1999.
Kulkarni A. R., Soppimath K. S., and Aminabhavi T. M.: Controlled release of diclofenac sodium from sodium alginate beads crosslinked with glutaraldehyde, Pharmaceuica Acta Helvetiae 74:29-36, 1999.
Ostberg T., Vesterhus L., and Graffner C.: Calcium alginate matrices for oral multiple-unit administration. 2. Effect of process and formulation factors on matrix properties, International Journal of Pharmaceutics 97: 183-193, 1993.
Pillay V.: Drug release modualation from cross-linked calcium alginate microdiscs, 2:Swelling, compression, and stability of the hydrodynamically-sensitive calcium alginate matrix and the associated drug release mechanisms, Drug Delivery 5: 35-46, 1998.
Pillay V., Dangor C. M., Govender T., Moopanar K. R., and Hurbans N.: lonotropic gelation: Encapsulation of indomethacin in calcium alginate gel discs, Journal of Microencapsulation 15: 215-226, 1998.
Pillay V., and Fassihi R.: In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract —i. Comparison of ph-responsive drug release and associated kinetics, Journal of Controlled Release 59: 229-242, 1999.
Kulkarni A. R., Soppimath K. S., Aminbahavi T. M., Dave A. M., and Mehta M. H.: Glutaraldehyde crosslinked sodium alginate beads containing liquid pesticide for soil application, Journal of Controlled Release 63: 97-105, 2000.
Kim Y. J., Yoon K. J., and Ko S. W.: Preparation and properties of alginate superabsorbent filament fibers crosslinked with glutaraldehyde, Journal of Applied Polymer Science 78: 1797-1804, 2000.
Tripathy T., Pandey S. R., Karmakar N. C. Bhagat R. P., and Singh R. P.: Novel flocculating agent based on sodium alginate and acrylamide, European Polymer Journal 35: 2057-2072, 1999.
Kim S. R., Yuk S. H., and Jhon M. S.: A semi-interpenetrating network system for a polymer membrane, European Polymer Journal 33: 1009-1014, 1997.
Wang X. P.: Preparation of crosslinked alginate composite membrane for dehydration of ethanol-water mixtures, Journal of Applied Polymer Science 77: 3054-3061, 2000.
Hertzberg S., Moen E., Vogelsang C., and Ostgaard K.: Mixed photo-crosslinked poly(vinyl alcohol) and calcium-alginate gels
Kim Dukjoon
Omidian Hossein
Park Haesun
Park Kinam
Qiu Yong
Meadows James H.
Medicus Associates
Purdue Research Foundation
Seidleck James J.
Zemel Irina S.
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