Hydrogels for orthopedic repair

Details Hydrogels for orthopedic repair Hydrogels for orthopedic repair

2006-03-07

2006-03-07

Wang, Shengjun (Department: 1617)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S423000, C424S400000, C424S484000, C424S487000

Reexamination Certificate

active

07008635

ABSTRACT:
Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

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