Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-17
1996-06-18
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514365, 514367, 514373, 514379, 514390, 514395, 514418, 514443, 514445, 514456, 514473, 5483027, 5483071, 548305, 548486, 548189, 548165, 548209, 548241, 548256, 5483067, 5483097, 549 55, 549 65, 549366, 549466, 549479, A61K 3144, C07D21106
Patent
active
RE0352799
ABSTRACT:
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives.
The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton.
The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.
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Kato Katsuaki
Kato Kazuo
Miwa Ichitomo
Mochida Ei
Murakami Kimihiro
McKane Joseph K.
Mochida Pharmaceutical Co. Ltd.
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