Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-12-17
2010-12-14
Zeman, Robert A. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S150100, C530S388400, C536S023530
Reexamination Certificate
active
07851170
ABSTRACT:
Hybridoma cell lines which produce and secrete monoclonal antibodies which selectively bind toMycobacterium aviumsubspeciesparatuberculosishave been produced. Cells ofM. aviumsubspeciesparatuberculosisin biological samples may be detected and quantified by contacting the sample with the antibodies to form aM. aviumsubspeciesparatuberculosis/antibody immunocomplex whenM. aviumsubspeciesparatuberculosisis present, which immunocomplex may then be detected. The monoclonal antibodies also may be incorporated into kits for the detection and quantification ofM. aviumsubspeciesparatuberculosis.
REFERENCES:
Lutz et al (1994 Journal of Immunology pp. 4099-4110).
Bannantine, John P., et al., “TheMycobacterium aviumsubsp.paratuberculosis. . . ”, Microbiology (2003), 149, pp. 2061-2069.
Bannantine, John P., et al., “Development and Characterization of Monoclonal Antibodies . . . ”, Clinical & Vaccine Immunology, May 2007, pp. 518-526, vol. 14 No. 5.
Bannantine, John P., et al., “Production and Characterization of Monoclonal Antibodies . . . ”Clinical & Vaccine Immunology, Mar. 2007, pp. 312-217 vol. 14.
Archie Nina A
Deck Randall E.
Fado John
Shaw Lesley
The United States of America as represented by the Secretary of
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