Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1985-05-02
1987-06-30
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4351723, 435253, 435317, 514 8, 514 12, 530350, 530351, 530395, 530808, 424 85, 424 88, 536 27, C12P 2100, C12N 1500, C12N 100, A61K 3900
Patent
active
046770640
ABSTRACT:
Human Tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.
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Creasey Abla A.
Ladner Martha B.
Lin Leo S.
Mark David F.
Van Arsdell Janelle N.
Cetus Corporation
Halluin Albert P.
Murashige Kate H.
Teskin Robin
Wiseman Thomas G.
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