Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1996-07-01
1998-05-26
Ulm, John
Drug, bio-affecting and body treating compositions
Lymphokine
530324, 514 2, 514 8, 514 12, 435 695, 435 711, 435326, 4351723, 4353201, 4352523, C07K 1452, A61K 3819
Patent
active
057560846
ABSTRACT:
The polypeptides of the present invention are produced and secreted in pro-B cells, so they may be used for diseases relating to undergrown or abnormal proliferation of hematopoietic cells, neuronal enhancement or depression, immunological enhancement and depression, for example, inflammatory diseases (rheumatoid arthritis, ulcerative colitis etc.), hematopoietic stemcytopenia after bone marrow transplantation, leukocytopenia, thrombocytopenia, B lymphopenia and T lymphopenia after chemotherapy, anemia, infectious diseases, cancer, leukocytosis, AIDS, neurodegenerative diseases (Alzheimer, multiple sclerosis etc.), prevention of treatment of neuronal injury, prevention of treatment of disorder of bone metabolism (osteoporosis etc.) or tissue repair. The DNA of the present invention may be utilized as an important and essential template in preparing the polypeptides of the present invention which are expected to possess various use or for diagnosis of an in the treatment of gene diseases.
REFERENCES:
Nagasawa et al, Proc. Natl. Acad. Sci. USA, 91:2305-2309 (1994).
Bowie et al. (1990) Science, vol. 247, pp. 1306-1310.
Tashiro et al. (1993) Science vol. 261, pp. 600-603.
Derynck et al. (1990) Biochemistry. vol. 29, pp. 10225-10233.
Weissenbach et al. (1980) Proc. Natl. Acad. Sci. vol. 77, No. 12, pp. 7152-7156.
Honjo Tasuku
Shirozu Michio
Tada Hideaki
Mertz Prema
Ono Pharmaceutical Co. Ltd.
Ulm John
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