Mpl ligand analogs

Details Mpl ligand analogs Mpl ligand analogs

1996-02-09

1998-05-26

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 695, 435325, 435358, 435360, 4352523, 4353201, A61K 3819, C07K 1452

Patent

active

057560838

ABSTRACT:
Mpl ligand analogs having one or more changed glycosylation sites as compared to a naturally occurring mpl ligand sequence of a corresponding number of amino acids are disclosed. The invention also relates to DNA sequences encoding mpl ligand analogs, recombinant plasmids and host cells for analog expression, and therapeutic compositions including such analogs.

REFERENCES:
patent: 5217881 (1993-06-01), Park
patent: 5218092 (1993-06-01), Sasaki et al.
Eaton et al., "Biological Activity of Human Thrombopoietin (TPO), the C-mpl Ligand and TPO Variants and the Chromosomal Localization of TPO", Blood, 84(10), (1994); Abstract No. 948, XP 000567760.
Hoffman, et al., "Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from Ser1 to Arg246", Biochemstry, 35(47), pp. 14849-14861, (1996).
Delorme et al. (1992) Biochemistry 31:9871-9876.
Bose et al. (1976). J. of Biol. Chem. vol. 251, No. 6, pp. 1659-1662.
Lok et al. (1994) Nature vol. 369 pp. 565-568.

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