Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-09-04
1999-12-21
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435 691, 4352523, 4353201, 536 232, 536 235, C12N 964, C12N 1557, C12N 1570, C12N 1585
Patent
active
060047941
ABSTRACT:
Isolated nucleic acids encoding a human serine protease PSP1, protein obtainable from the nucleic acids, recombinant host cells transformed with the nucleic acids, oligonucleotides and primer pairs specific for PSP1 polymorphisms and use of the protein and nucleic acid sequences are disclosed.
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Mercken et al., "Characterization of Human Presenilin 1 Using N-terminal Specific Monoclonal Antibodies: Evidence that Alzheimer Mutations Affect Proteolytic Processing", FEBS Letters, vol. 389, pp. 297-303 (1996).
Lipinska, "Sequence Analysis and Regulation of the htrA Gene of Escherichia coli: a o.sup.32 -Independent Mechanism of Heat-inducible Transcription", Nucleic Acids Research,vol. 16, pp. 10053-10067 (1988).
Ohno, et al., Genbank Accession No. D87258 (1996).
Zumbrunn, J., et al., FEBS Letters, vol. 398, "Primary structure of a putative serine protease specific for IGF-binding proteins", pp. 187-192, 1996.
Browne Michael Joseph
Clinkenbeard Helen Elizabeth
Creasy Caretha Lee
Karran Eric Howard
Livi George Pietro
Achutamurthy Ponnathapura
Baumeister Kirk
King William T.
Moore William W.
SmithKline Beecham Corporation
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