Human scad family molecules

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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435 6, 4352523, 4353201, 536 231, 536 232, 536 235, C12N 904, C12N 120, C12N 1500, C12Q 168, C07H 2102

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active

060571403

ABSTRACT:
The invention provides human SCAD family molecules (HSFM) and polynucleotides which identify and encode HSFM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSFM.

REFERENCES:
patent: 5731195 (1998-03-01), Simon et al.
Koivuranta et al. Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase. Biochem. J. 304:787-792, 1994.
Adams et al. Genebank Accession Number AA295728, Apr. 1997.
Hillier et al. Genebank Accession Number AA152345, Dec. 1996.
Watson et al. Recombinant DNA, 2nd edition. WH Freeman and Company, New York, pp. 453-454, Feb. 1994.
Baker, M.E., "enoyl-acyl-carrier-protein reductase and Mycobacterium tuberculosis InhA do not conserve the Tyr-Xaa-Xaa-Lys motif in mammalian 11.beta.-and 17.beta.hyroxysteriod dehydrogenase", Biochem. J., 309: 1029-1030 (1995).
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Roe, C.R., et al., "2, 4-Dienoyl-Coenzyme a Reductase Deficiency: A Possible New Disorder of Fatty Acid Oxidation", J. Clin. Invest., 85:1703-1707 (1990).
Chai, Xiyun, et al., "Cloning of a cDNA for Liver Microsomal Retinol Dehydrogenase", J. Biol. Chem., 270: 3900-3904 (1995).
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Simon, A. et al., (Direct Submission), GenBank Sequence Database (Accession U43559), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1616643; GI 1616654).
Chai, X. et al., (Direct Submission), GenBank Sequence Database (Accession U18762), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 841196; GI 841197).
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