Human retrovirus-related products and methods of diagnosing and

Details Human retrovirus-related products and methods of diagnosing and Human retrovirus-related products and methods of diagnosing and

1985-09-30

1988-10-11

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

436518, 436531, 436813, 436822, 530300, 530327, 530328, 530387, 530820, 530826, 530827, 530828, C12Q 170, G01N 33543, G01N 33545

Patent

active

047771275

ABSTRACT:
A human endogenous retrovirus-related Mv-75,000 protein, containing the decapeptide sequence Glutamic Acid-Asparagine-Proline-Serine-Glutamine-Phenylalanine-Tyrosine-Glutamic Acid-Arginine-Leucine, a synthetic undecapeptide Sp-23 based on the decapeptide, and specific polycolonal and monoclonal antibodies and specific nucleic acid probes are used as specific reagents for the detection and treatment of tumors such as renal cell adenocarcinoma and choriocarcinoma, among others, and placental disorders including blighted ova, hydatiform and destructive moles.

REFERENCES:
patent: 4629783 (1986-12-01), Cosand
Suni, J. et al., Int. Jour. Cancer 28(5): 559-566 (1981).
Sutcliffe, J. G. et al., Nature, 287: 801-805 (1980).
Hudson, L. et al., in "Practical Immunology" (Blackwell Scientific Publications, Oxford) pp. 5-9, (1980).
T. I. Bonner et al., "Cloned Endogenous Retroviral Sequences from Human DNA", 79 Proc. Natl. Acad. Sci. U.S.A., 4709-4713 (Aug. 1982).
S. J. O'Brien et al., "Mapping of Endogenous Retroviral Human Chromosome 18", 303 Nature 74-77 (May 1983).
K. Robbins et al., "In Vivo Identification of Transforming Gene Product of Simian Sarcoma Virus", 218 Science 1131-1133 (Dec. 1982).
T. Wahlstrom et al., "Monoclonal Antibody Defining a Human Syncytiotrophoblastic Polypeptide Immunologically Related to Mammalian Retrovirus Structural Protein p 30", 5 Placenta 465-474 (Oct. 1984).
J. Suni et al., "Human Placental Syncytiotrophoblastic Mr 75,000 Polypeptide Defined by Antibodies to a Synthetic Peptide Based on a Cloned Human Endogenous Retroviral DNA Sequence", 81 Proc. Natl. Acad. Sci. U.S.A. 6197-6201 (Oct. 1984).

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