Method for treatment of glaucoma with nitrogen containing guanyl

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof

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514252, 514257, 514913, A61K 3338, A61K 3150, A61K 31505

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active

055002307

ABSTRACT:
The present invention relates to a method of treating cranial fluid volume dysfunctions such as glaucoma in an individual, comprising administering compounds which effect an increase in cyclic GMP at the site of the dysfunction or at the site of synthesis or removal of the accumulating fluid. In particular, the method of treatment involves the topical use of hydralazine, non-organic nitrites or nitroglycerine, and the systematic use of hydralazine or non-organic nitrites.

REFERENCES:
patent: 3843782 (1974-10-01), Krezanoski et al.
patent: 4396625 (1983-08-01), Yamamori et al.
patent: 4425345 (1984-01-01), Horlington et al.
patent: 4425346 (1984-01-01), Horlington
patent: 4477466 (1984-10-01), Shepard
patent: 4496544 (1985-01-01), Needleman
patent: 4508712 (1985-04-01), Needleman
patent: 4532135 (1985-07-01), Edwards
patent: 4590207 (1986-05-01), Tomiuga et al.
patent: 4668506 (1987-05-01), Bawa
patent: 4696932 (1987-09-01), Jacobson et al.
patent: 4771059 (1988-09-01), Bodor
patent: 4783444 (1988-11-01), Watkins et al.
patent: 4826879 (1989-05-01), Yamamoto et al.
patent: 4861755 (1989-08-01), Breiphol et al.
patent: 4912111 (1990-03-01), Sank et al.
Antunes-Rodrigues, J. et al., Atrial natriuretic factor inhibits dehydration- and angiotensin II-induced water intake in the conscious, unrestrained rat, Proc. Natl. Acad. Sci. USA 82:8720-8723 (Dec. 1985).
Bergey, J. L. et al., Effects of Atriopeptins I, II And III On Atrial Contractility, Sinus Nodal Rate (Guinea Pig) And Agonist-Induced Tension In Rabbit Aortic Strips, Eur. J. Pharmacol. 110:277-281 (1985).
Bianchi, C. et al., Localization and characterization of specific receptors for atrial natriuretic factor in the ciliary processes of the eye, Current Eye Research 5(4) :283-293 (1986).
Bianchi, C. et al., Radioautographic Localization of .sup.125 I-Atrial Natriuretic Factor Binding Sites in the Brain, Neuroendocrinol. 44:365-372 (1986).
Cantin, M. et al., The Heart and the Atrial Natriuretic Factor, Endocrine Reviews 6(2):107-127 (1985).
Cloix, J. F. et al., Recent Advances On Endogenous Na.sup.+, K.sup.+ -ATPase Inhibitors: Clinical Investigation and Purification, Clin. and Exper.-Theory and Practice A7 (5&6): 663-672 (1985).
de Bold, A. J., Atrial Natriuretic Factor: A Hormone Produced by the Heart, Science 230:767-770 (Nov. 15, 1985).
Debowska-Weissowa, J. et al., Influence of Nitroglycerine On The Level of Intraocular Pressure, Klin. Oczna 88:153-154 (1986).
Erne, P. et al., Vasodilating Agents and Platelet Function: Intracellular Free Calcium Concentration, Cyclic Nucleotides, and Shape-Change Response, J. Cardiovasc. Pharmacol. 8 (Suppl. 8) :S102-S106 (1986).
Fiink, E. B., Heavy Metal Poisoning, in Beeson, P. B. et al., eds., Cecil Textbook of Medicine, Fifteenth Edition, Vol. 1, W. B. Saunders Co., Philadelphia, pp. 76-82 (1979).
Fitts, D. A. et al., Diuresis and Reduction of Salt Appetite by Lateral Ventricular Infusions of Atriopeptin II, Brain Res. 348:118-124 (1985).
Focosi, F. et al., Glyceral Trinitrate And Intraocular Pressure: A Tonographic Study In Man, Annali di Ottalmologia e Clinica Oculistica CXII (5):361-367 (1986).
Fransen, L. et al., Neonatal opthalmia in the developing world: Epidemiology, etiology, management and control, Int. Opthalmol. 11:189-196 (1988).
Gibson, T. R. et al, Autoradiographic Localization and Characterization of Atrial Natriuretic Peptide Binding Sites in the Rat Central Nervous System and Adrenal Gland, J. Neurosci. 6(7):2004-2011 (Jul. 1986).
Golden, B. et al., Intraocular Infections, in Hoeprich, P. D., ed., Infectious Diseases, pp. 1259-1262, (1972).
Goodman et al., Vasodilators, The Pharmacological Basis of Therapeutics, 7th Edition, MacMillan Publishing Company, N.Y., pp. 795-798 (1986).
Kostyuchenkov, V. N. et al., Effect of adreno- and sympatholytic agents on opthalmotonus, Chem. Abstracts 76:11, Abstract No. 110e (1972).
Krupin, T. et al., Increased intraocular pressure following topical azide or nitroprusside, Invest. Opthalmol. Vis. Sci. 16 (11): 1002-1007 (Nov. 1977).
Krupin, T. et al., Topical vanadate lowers intraocular pressure in rabbits, Invest. Opthalmol. Vis. Sci. 19 (11): 1360-1363 (Nov. 1980).
Lide, D. R., ed., CRC Handbook of Chemistry and Physics, 72nd Edition, CRC Press, Inc., pp. 4-48, 4-70, 4-72, 4-88, 4-99, 4-103 (1991-1992).
Lynch, D. R. et al., Atrial natriuretic factor receptors in rat kidney, adrenal gland, and brain: Autoradiographic localization and fluid balance dependent changes, Proc. Natl. Acad. Sci. USA 83:3357-3361 (May 1986).
Masotto, C. et al., Inhibition of Spontaneous or Angiotensin II-Stimulated Water Intake by Atrial Natriuretic Factor, Brain Res. Bull. 15:523-526 (1985).
Masuda, A. et al., Effect of hypotension induced by trimethaphan and nitroglycerine on intraocular pressure in man, Jap. J. Anesthesiol. 32:213-216 (1983).
Mittag, T. W. et al., Atrial natriuretic peptide (ANP), guanylate cyclase, and intraocular pressure in the rabbit eye, Current Eye Research 6 (10):1189-1196 (1987).
Mutschler, E., Sonstige Vasodilatatoren met direktem Angriff an der glatten Muskulatur, Arzneimittelwirkungen, Wissenschaftliche Verlagsgesellschaft, Stuttgart, pp. 461-462 (1986).
Napier, M. A. et al., Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues, Proc. Natl. Acad. Sci. USA 81:5946-5950 (Oct. 1984).
Nathanson, J. A., Atriopeptin-Activated Guanylate Cyclase in the Anterior Segment, Invest. Opthalmol. Vis. Sci. 28:1357-1364 (Aug. 1987).
Nathanson, J. A. et al., "Second Messengers"in the Brain, Sci. Amer. 237:108-119 (1977).
Nathanson, J. A., Nitrovasodilators as a New Class of Ocular Hypotensive Agents, J. Pharmacol. and Exp. Therap. 260(3):956-965 (1992).
Needleman, P. et al., Drugs Used for the Treatment of Angina: Organic Nitrates, Calcium Channel Blockers, and .beta.-Adrenergic Antagonists, in Goodman et al., The Pharmacological Basis of Therapeutics, pp. 806-816, 1985.
Physician's Desk Reference, 38th Edition, p. 1033 (1984).
Saman, K. et al., Nitroglycerin A Glaukom, Cs. Oftalmologie 31: 434-439 (1975).
Samson, W. K. Dehydration-Induced Alterations In Rat Brain Vasopressin And Atrial Natriuretic Factor Immunoreactivity, Endocrinol. 117 (3): 1279-1281 (1985).
Sasaki, T. et al., The Effect of .alpha.-Human Atrial Natriuretic Polypeptides (.alpha.-hANP) on Intraocular Pressure in Albino Rabbits. First Report: In Albino Rabbits with Normal Intraocular Pressure, Nippon Ganka Gakki Zasshi 90 (10):1232-1234 (1986).
Scarpelli, P. T. et al., Malignant Hypertension. Evaluation by Fluoroscopic Retinography of the Long-Term Effects of Antihypertensive Treatment on Eyeground changes, Giorn. Gerontol. 24:845-858 (1976).
Standaert, D. G. et al., Atriopeptin: potent hormone and potential neuromediator, Trends in Neurosciences 8:509-511 (Dec. 1985).
Steardo, L. et al., Brain Barrier Tissues: End Organs for Atriopeptins, Science 235:470-473 (Jan. 23, 1987).
Sugrue, F. F. et al., Synthetic atrial natriuretic factor lowers rabbit intraocular pressure, Eur. J. Pharmacol. 130:349-350 (1986).
Thulesius, O., Cardiovascular Pharmacology of Molsidomine, Biblthca Cardiol. 38: 234-243 (1984).
Tomiuga, T. et al., Effects of Organic Nitrates on Intraocular Pressure in Rabbits, Atarashii Ganka 2 (4): (1985).
Waldman, S. A. et al., Atrial Natriuretic Factor Selectively Activates Particulate Guanylate Cyclase and Elevates Cyclic GMP in Rat Tissues, J. Biol. Chem. 259 (23):14332-14334 (Dec. 10, 1984).
Whitworth, C. C. et al., Use of Nitrate and Nitrite Vasodilators by Glaucomatous Patients, Arch. Opthalmol. 71:492-496 (Apr. 1964).
Wilensky, J. T. et al., Acute Systemic Hypertension After Conjunctival Instillation of Phenylephrine Hydrochloride, Am. J. Opthalmol. 76 (1):156-157 (1973).
Windholz, M. et al., eds., Sodium Nitrite, The Merck Index, Tenth Edition, Merck & Co., Inc., Rahway, N.J., p. 1238 (1983).
Winquist, R. J. et al., Atrial natriuretic factor elicits and endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle, Proc. Natl. Acad. Sci. USA 81:7661-7664 (Dec. 1984).
Winquist, R. J. e

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