Human recombinant collagen in the milk of transgenic animals

Details Human recombinant collagen in the milk of transgenic animals Human recombinant collagen in the milk of transgenic animals

1994-01-18

1997-09-16

Stanton, Brian R.

Food or edible material: processes, compositions, and products

Products per se, or processes of preparing or treating...

Protein, amino acid, or yeast containing

119DIG1, 4241571, 424535, 426580, 435273, 4351723, 514801, 530832, 800 2, A23C 9152, A23J 120, C07K 100, C12N 1506

Patent

active

056678398

ABSTRACT:
Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.

REFERENCES:
patent: 4798800 (1989-01-01), Timpl et al.
patent: 5071878 (1991-12-01), Herschler et al.
patent: 5215904 (1993-06-01), Gould et al.
patent: 5227301 (1993-07-01), Turner et al.
Stacey et al., "Perinatal Lethal Osteogenesis Imperfecta in Transgenic Mice Bearing an Engineered Mutant pro-.alpha.1(I) Collagen Gene", Nature, 332:131-36 (1988).
Robertson E.J., Trends in Genetics (TIG) (1986) 2:9-13.
Krimpenfort et al. 1991. Biotechnology 9: 844-847.
Wall, 1996, Theriogenology 45: 57-68.
Houdebine, 1994, Journal of Biotechnology, 34: 269-287.
Hennighausen, 1990. Protein Expression & Purification 1:3-8.
Clark et al., 1987. TIBTECH 5: 20-24.
Prockop et al. 1984. The New England Journal of Medicine 311(6): 376-386.
Fisler et al. 1985. Int. J. Obes. 9(5): 335-346, Abstract Only.
Sigma Chemical Catalog, 1992; Sigma Chemical Company, p. 274.

Affiliated with

Also associated with

Rating

Human recombinant collagen in the milk of transgenic animals does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human recombinant collagen in the milk of transgenic animals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human recombinant collagen in the milk of transgenic animals will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-216528