Human preproinsulin-like growth factor I

Details Human preproinsulin-like growth factor I Human preproinsulin-like growth factor I

1986-11-20

1990-10-16

Warren, Charles F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 694, 4351723, 435235, 43525233, 4353171, 435320, 514 2, 530303, 530324, 530399, C07H 2104, C12N 1500

Patent

active

049636650

ABSTRACT:
The invention provides DNA sequences encoding a human preproinsulin-like growth factor I protein and novel extension peptides. A novel preproinsulin-like growth factor I protein and novel extension peptides are also provided. The present invention further provides a human IGF-I gene which has been sequenced and which encodes at least two preproinsulin-like growth factor-I proteins. Various genes and DNA sequences useful in producing essentially pure mature IGF-I, preproinsulin-like growth factor I proteins and IGF-I gene related proteins are also provided.

REFERENCES:
Jansen et al., 1983, Nature, 306:609-611.
Bell et al., 1985 (Oct.), PNAS 82:6450-6454.
Rotwein et al., 1986, J. Biol. Chem., 261:4828-4832.
Rotwein, 1986, PNAS, 83:77-81.
Ernst Rinderknecht and Rene E. Humbel, J. Biol. Chem., 253:2769 (1978).

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