Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-03-08
1996-03-26
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352523, 43525411, 4353201, 536 232, 536 243, C12N 1557, C12N 1563, C12N 121, C12N 510
Patent
active
055019692
ABSTRACT:
Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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Smith, S. M. and Gottesmann, M. M., Activity and Deletion Analysis of Recombinant Human Cathepsin L Expressed in E. Coli J. Biol. Chem., 264:20487-20495 (1989).
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Adams Mark D.
Blake Judith A.
Drake Fred H.
Fitzgerald Lisa M.
Fraser Claire M.
Ferraro Gregory D.
Grimes Eric
Human Genome Sciences Inc.
Olstein Elliot M.
Wax Robert A.
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