Human manganese superoxide dismutase (hMn-SOD)

Chemistry: molecular biology and microbiology – Vector – per se

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435189, 4352542, C12N 1563, C12N 1581, C12N 1553

Patent

active

054361621

ABSTRACT:
The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.

REFERENCES:
patent: 3920521 (1975-11-01), Michelson et al.
patent: 3997402 (1976-12-01), Michelson
patent: 4029819 (1977-06-01), Michelson
patent: 4751180 (1988-06-01), Cousens et al.
patent: 5115097 (1992-05-01), Uda et al.
patent: 5196335 (1993-03-01), Groner
patent: 5240847 (1993-08-01), Heckl et al.
patent: 5246847 (1993-09-01), Hartman et al.
patent: 5260204 (1993-11-01), Heckl et al.
patent: 5270195 (1993-12-01), Hartman et al.
Urdea, M. S. (1983) Proc. Natl. Acad. Sci, USA 80, 7461-7465.
Bannister and Bannister, "Isolation and Characterization of Superoxide Dismutase," Meth. Enzymol. 105:88-93 (1984).
Nakagawa, S., et. al., Bio techology 5, 824-827, (1987).
Barra et al., The Primary Structure of Human Liver Manganese Superoxide Dismutase, Journal of Biological Chemistry 259(20):12595-12601 (1984).
Barra et al., Primary Structure of Mangano Superoxide Dismutase From Human Liver, Oxyradicals and Their Scavenger Systems, vol. 1, 336-339 (1983).
Beck et al., Human Mn superoxide dismutase cDNA sequence, Nucleic Acids Research 15(21):9076 (1987).
Bridges et al., Distribution of Iron-Containing Superoxide Dismutase in Vascular Plants, Plant Physiology 68:275-278 (1981).
English abstract of German patent document 2 417 508 (1974).
Heckl, K., Isolation of cDNAs encoding human manganese superoxide dismutase, Nucleic Acids Research 16:6224 (1988).
Ho et al., Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase, FEBS Letters 229(2):256-260 (1988).
Jabusch et al., Some Sulfhydryl Properties and Primary Structure of Human Erythrocyte Superoxide Dismutase, Biochemistry 19:2310-2316 (1980).
Jay et al., Gene expression: chemical synthesis of E. coli ribosome binding sites and their use in directing the expression of mammalian proteins in bacterial, Nucleic Acids Res. 10: 6319-6329 (1982).
Kozak, M., Analysis of Ribosome Binding Sites from the s1 Message of Reovirus, J. Mol. Biol. 156:807-820 (1982).
Kozak, M., Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes, Nucleic Acids Research 9(20):5233-5252 (1981).
Lehninger, A. L., Biochemistry, The Molecular Basis of Cell Structure and Function, 2nd edition, Worth Publishers, p. 149, 1975.
Marres et al., Nucleotide sequence analysis of the nuclear gene coding for manganese superoxide dismtase of yeast mitochondria, a gene previously assumed . . . , Eur. J. Biochem. 147:153-161 (1985).
Sharp et al., Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes, Nucleic Acids Research 14(13):5125-5143 (1986).
Touati, D., Cloning and Mapping of the Manganese Superoxide Dismutase Gene (sodA) of Escherichia coli K-12, Journal of Bacteriology 155(3):1078-1087 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human manganese superoxide dismutase (hMn-SOD) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human manganese superoxide dismutase (hMn-SOD), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human manganese superoxide dismutase (hMn-SOD) will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-739161

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.