Human leukemia inhibitory factor

Details Human leukemia inhibitory factor Human leukemia inhibitory factor

1992-09-22

1995-08-22

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 530395, 514 2, 514 8, 514 12, A61K 3702, C07K 710, C07K 900

Patent

active

054438250

ABSTRACT:
Leukemia-inhibitory factor (LIF) has been produced in essentially pure form from murine or human sources. A method of purifying this LIF is disclosed, as well as polypeptides having LIF activity which are not identical in amino acid sequence to any naturally occurring form of LIF. The polypeptides can be used for hindering the proliferation of myeloid Leukemia cells.

REFERENCES:
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Deutscher, Murray P.: Methods in Enzymology 182:71, 603, 609 (1990) "Guide to Protein Purification".
M. Tomida et al., FEBS Letters 178:291-296, Dec. 1984.
M. Tomida et al., Journal of Biological Chemistry 259: 10978-10982, Sep. 1984.
D. Lowe et al., DNA 8:351-359, 1989.
Moreau et al. "Capacity of Alloreative Human T Clones to Produce Factors", Ann. Inst. Pasteur/Immunol. 137C:25-37 (Jan./Feb. 1986).
Moreau et al. "Leukaemia inhibitory factor is identical to the myeloid growth factor . . . ", Nature 336:690-692, (Dec. 1988).
Moreau et al. "Characterization of a factor . . . " J. Immunol. 138(11):3844-3849 (Jun. 1987).
Koopman et al., "A Factor Produced by Feeder Cells . . . " Exp. Cell. Res. 154:233-242 (1984).
Williams et al. "Myeloid leukaemia inhibitory factor . . . " Nature 336:684-687 (Dec. 1988).
Yamamori et al. "The Cholinergic Neuroual Differentation Factor . . . " Science 246:1412-1416 (Dec. 1989).
Fukuda "Purification and partial characterization of a cholinergic neuronal differential factor . . . " PNAS 82:8795-8799 (Dec. 1985).
Huynh et al. "Constructing and Screening cDNA libraries . . . " pp. 49-78 in DNA Cloning, edited by Glover (1985).
Lathe, "Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data", J. Mol. Biol. 183:1-12 (1985).
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Tomida et al., FEBS Letters 178:291-296, Dec. 1984.
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Schulz et al., pp. 14-16 in Principles of Protein Structure.
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