Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1995-01-19
1997-08-12
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
530350, 5303873, 435 691, 536 235, C12N 912, C07K 14705
Patent
active
056564732
ABSTRACT:
The present invention provides for a gene, designated as dmk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the dmk gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between Dmk and agents that initiate signal transduction through binding to Dmk.
REFERENCES:
Barinaga, Science, vol. 264, 772, 1994.
Jennings et al., PNAS, vol. 90, 2895, 1993.
Nakagawara et al., Molecular and Cellular Biology, vol. 14, 759, 1994.
Rojas Eduardo A.
Valenzuela David M.
Cobert Robert J.
Kempler Gail M.
Regeneron Pharmaceuticals Inc.
Teng Sally P.
Walsh Stephen G.
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