Human c-Maf compositions and methods of use thereof

Details Human c-Maf compositions and methods of use thereof Human c-Maf compositions and methods of use thereof

2005-08-23

2005-08-23

Woitach, Joseph (Department: 1632)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Geomicrobiological testing

C435S325000, C424S093100, C536S023100

Reexamination Certificate

active

06933125

ABSTRACT:
Isolated nucleic acid molecules encoding human c-Maf, and isolated c-Maf proteins, are provided. The invention further provides antisense nucleic acid molecules. recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human c-Maf transgene. The invention further provides human c-Maf fusion proteins and anti-human c-Maf antibodies. Methods of using the human c-maf compositions of the invention are also disclosed, including methods for detecting human c-Maf activity in a biological sample, methods of modulating human c-Maf activity in a cell, and methods for identifying agents that modulate the activity of human c-Maf.

REFERENCES:
patent: WO 97/39721 (1997-10-01), None
Kataoka et al. Molecular and Cellular Biology, Apr. 1995, vol. 15(4), pp. 2180-2190.
Hedge et al. Molecular and Cellular Biology, May 1998, vol. 18(5), pp. 2729-2737.
Hodge et al. Science. Dec. 1996, vol. 13;274(5294), pp. 1903-1905.
Andrews, N.C. et al. “The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to thev-mafoncogene,”PNAS., USA, 90 (1993).
Blank et al. “Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression,”Blood89(11):3925-35.
Chesi, Marta et al. (1998) “Frequent Dysregulation Of The c-maf Proto-Oncogene at 16q23 By Translocation of An Ig Locus In Multiple Myeloma”Blood.91(12):4457-4463.
Ebert et al. “A Moloney MLV-rat somatotropin fusion gene produces biologically active somatotropin in a transgenic pig,”Mol. Endocrinol. 2(3):277-83 (1988).
Fujiwara, K.T. et al. “Two new members of themafoncogene family,mafKandmaff, encode nuclear b-Zip proteins lacking putative trans-activator domain,”Oncogene, 8:2371-2380 (1993).
Hammer et al. “Genetic engineering of mammalian embryos,”J. Animal Sci.63(1):269-78 (1986).
Ho, I-Cheng et al. (1996) “The Proto-Oncogene c-maf IS Responsible For Tissue-Specific Expression Of Interleukin-4”,Cell, 85(7):973-983.
Igarashi, K. et al. “Activity and Expression of Murine Small Maf Family Protein MafK,”The Journal of Biological Chemistry, 270(13):7615-7624 (Mar. 31, 1995).
Kataoka, K. et al. “Small Maf Proteins Heterodimerize with Fos and May Act as Competitive Repressors of the NF-E2 Transcription Factor,”Mol. Cell. Biol., 15:2180-90 (1995).
Kataoka, K. et al. “Structure-Function Analysis of themafOncogene Product, a Member of the b-zip Protein Family,”Journal of Virology, 67(4):2133-2141 (Apr. 1993).
Kataoka, K et al. GenBenk™ Accession No. D28596 for Chicken gene for c-maf proto-oncogene product c-Maf, short from complete cds and long form 1stexon.
Kurchner, C. et al. GenBank™ Accession No. S74567 for c-maf=c-Maf protein (proto-oncogene) [mice, BALB/c, cerebellum, mRNA, 2736 nt].
Kurschner, C. et al. “ThemafProto-oncogene Stimulates Transcription from Multiple Sites in a Promoter That Directs Purkinje Neuron-Specific Gene Expression,”Mol Cell Biol, 15:246-54 (1995).
Mullins et al. “Transgenesis in the rat and larger mammals,”J. Clin. Invest.97(7):1557-60 (1996).
Swaroop, A. et al. “A conserved retina-specific gene encodes a basic motif/leucine zipper domain”,Proc. Natl. Acad. Sci. USA, 89:266-270 (Jan. 1992).
Toki et al. “Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif,”Oncogene14:1901-10.
Wall et al. “Transgenic dairy cattle: genetic engineering on a large scale,”J. Dairy Sci.80(9):2213-24 (1996).
Sakai, M. et al. “Ratmafrelated genes: specific expression in chondrocytes, lens and spinal cord,”Oncogene14:745-50 (1997).

Affiliated with

Also associated with

Rating

Human c-Maf compositions and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human c-Maf compositions and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human c-Maf compositions and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3439955