Drug – bio-affecting and body treating compositions – In vivo diagnostic or in vivo test agent which contains an...
Patent
1998-11-24
2000-08-29
Patterson, Jr., Charles L.
Drug, bio-affecting and body treating compositions
In vivo diagnostic or in vivo test agent which contains an...
4241391, 435 71, 435196, 5303879, A61K 3846, C12N 916
Patent
active
061105074
ABSTRACT:
The present invention provides a human 3-hydroxyisobutyryl-coenzyme A hydrolase (HIBCOH) and polynucleotides which identify and encode HIBCOH. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for the prevention and treatment of diseases associated with expression of HIBCOH, as well as diagnostic assays.
REFERENCES:
Taniguchi, K, et al. (1996) Hepatology 24(6), 1395-1398.
Shimomura, Y. et al., "Purification and Partial Characterization of 3-Hydroxyisobutyryl-coenzyme A Hydrolase of Rat Liver", J. Biol. Chem., 269:14248-14253 (1994).
Corkey, B.E. et al., "Regulation of the Branched Chain .alpha.-Ketoacid Pathway in Liver", J. Biol. Chem., 257: 9668-9676 (1982).
Brown, G.K. et al., ".beta.-Hydroxyisobutyryl Coenzyme A Deacylase Deficiency: A Defect in Valine Metabolism Associated with Physical Malformations", Pediatrics, 70: 532-538 (1982).
Hawes, J.W. et al., "Primary Structure and Tissue-specific Expression of Human .beta.-Hydroxyisobutyryl-coenzyme A Hydrolase", J. Biol. Chem., 271: 26430-26434 (1996).
Wilson, R. et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", Nature, 368: 32-38 (1994).
Wilson, R. et al., (Direct Submission), GenBank Sequence Database (Accession U00050), National Center for Biotechnology Information, National Library of Medicine, Bethesada, Maryland, 20894.
Adams, et al. "Prostste gland I.H. sapiens cDNA 5' end similar to 3-hydroxyisobutyryl-coenzyme A hydrolase," EMBL Database entry HSZZ75461; Acc No. AA370306 (Apr. 18, 1997).
Hillier, et al. "Soares pregnant uterus NbHPU. H. sapiens cDNA clone 490601 5' similar to WP:F09F7.4 CE00689 Enoyl-CoA hydratase," EMBL Database entry HSAA2838; Acc No. AA102838 (May 17, 1997).
Bandman Olga
Corley Neil C.
Guegler Karl J.
Shah Purvi
Incyte Genomics Inc.
Patterson Jr. Charles L.
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