HMG-CoA reductase inhibiting substituted pryido (2,3-d) pyrimidi

Details HMG-CoA reductase inhibiting substituted pryido (2,3-d) pyrimidi HMG-CoA reductase inhibiting substituted pryido (2,3-d) pyrimidi

1990-01-02

1991-12-24

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D47102

Patent

active

050753118

ABSTRACT:
New substituted pyrido(2,3-d)pyrimidines of the formula ##STR1## can be prepared by reduction of corresponding pyrido(2,3-d)-pyrimidines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used to inhibit HMG-CoA reductase.

REFERENCES:
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4613610 (1986-09-01), Wareing
patent: 4761419 (1988-08-01), Picaradi et al.

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