HLA-DR antigen gene and its nucleotide sequence and its use

Details HLA-DR antigen gene and its nucleotide sequence and its use HLA-DR antigen gene and its nucleotide sequence and its use

1994-06-22

1997-09-02

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2431, C12Q 168, C07H 2104

Patent

active

056630476

ABSTRACT:
We have found a novel subtype DRw14c and sequenced the nucleotide sequence thereof. DRw14 associated genes can be genetically typed at the DNA level using DRB1-14c sequence specific oligonucleotide probes such as F142 and F144 of the invention. The present invention overcomes the disadvantages of serological typing and provides a reagent that determines a type of a HLA-DR antigen. More specifically, the invention provides an oligonucleotide probe capable of identifying subtypes of a HLA-DR antigen precisely and a reagent containing the oligonucleotide probe. Furthermore, the invention provides a method of detecting a novel HLA-DR antigen.

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