Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-12
1999-02-23
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 93, A61K 3144, C07D22116
Patent
active
058744428
ABSTRACT:
"Novel compounds, such as: ##STR1## are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds."
REFERENCES:
patent: 4144337 (1979-03-01), Bastian
patent: 4282233 (1981-08-01), Villani
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 4831042 (1989-05-01), Villani
patent: 4863931 (1989-09-01), Schumacher et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5104876 (1992-04-01), Piwinski et al.
patent: 5141851 (1992-08-01), Brown et al.
patent: 5151423 (1992-09-01), Piwinski et al.
patent: 5185248 (1993-02-01), Barbacid et al.
patent: 5204348 (1993-04-01), Fukazawa et al.
patent: 5393890 (1995-02-01), Syoji et al.
patent: 5405843 (1995-04-01), Fukazawa et al.
Winograd, B. Oxford Textbook of Oncology, vol. 1, ed. by Peckham, M. et al. (Oxford University Press, Oxford), pp. 486-495 (1995).
Cell, 65, 1-4 (1991). Gibbs, J.B.
J. Biol. Chem., 266, (24) 15575-15578 (1991). Goldstein, J.L. et al.
Proc. Natl. Acad. Sci. USA, 87, 3042-3046 (1990). Jackson, J.H. et al.
Proc. Natl. Acad. Sci. USA, 88, 8631-8635 (1991). Casey, P.J. et al.
Nature, 356, 713-715 (1992). Basu, T.N. et al.
Proc. Natl. Acad. Sci. USA, 87, 7541-7545 (1990). Schaber, M.D. et al.
J. Biol. Chem., 265, (25) 14701-14704 (1990). Satoh, T. et al.
Proc. Natl. Acad. Sci. USA, 87, 7926-7929 (1990). Reiss, Y. et al.
Cell, 62, 81-88 (1990). Reiss, Y. et al.
Biochemistry, 31, 3800-3807 (1992). Pomplians, D.L. et al.
Science, 260, 1934-1937. Kohl, N.E. et al. (1993).
Science, 260, 1937-1942. James, G.L. et al. (1993).
J.J. Piwinski, et al., J. Med. Chem., 34, (1) 457-461 (1991).
B. Masci, J. Chem. Soc., Chem. Commun., 1262-1263 (1982).
B. Masci, J. Org. Chem., 50, 4081-4087 (1985).
S.M. Sebti, et al., Proc. Ann. Meeting AM Assoc. Cancer Res., 33:A2217 (1992).
F.J. Villani, et al., J. Med. Chem., 15, (7) 750-754 (1972).
M.M. Billah, et al., Lipids, 26, (12) 1172-1174 (1991).
E.J. Villani, et al., Arzneim.-Forsch./Drug Res., 36(II), 1311-1314 (1986).
K. Yokoyama et al, Proc. Natl. Acad. Sci. USA, 88, 5302-5306 (1991).
C.A. Omer et al, Biochemistry, 32, 5167-5176 (1993).
M.E. Furth et al, J. Virology, 43, 294-304 (1982).
J. Price et al, Proc. Natl. Acad. Sci. USA, 84, 156-160 (1987).
R. Khosravi-Far et al, Cell Growth & Differentiation, 3, 461-468 (1992).
Advanced Organic Chemistry, 3rd ed., Part B: Reactions and Synthesis (1990), 571-573. Name of Author Not Provided.
R. Sarges, et al, J. Med. Chem., 33, 1859-1865 (1990).
S.L. Graham, Exp. Opin. Ther. Patents, 5, 1269-1285 (1995).
L. Sepp-Lorenzino et al, Cancer Res., 55, 5302-5309 (1995).
T. Nagasu et al, Cancer Res., 55, 5310-5314 (1995).
Chemical Abstracts, 121 (1994) 301326v. Schnorrenberg, G. et al.
Doll Ronald J.
Kelly Joseph M.
Mallams Alan K.
Njoroge F. George
Remiszewski Stacy W.
Huang Evelyn
Jeanette Henry C.
Kight John
Magatti Anita W.
Schering-Plough Corporation
LandOfFree
Tricyclic amides useful for inhibition of G-protein function and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tricyclic amides useful for inhibition of G-protein function and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic amides useful for inhibition of G-protein function and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-307326