Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds virus or component thereof
Patent
1995-06-07
1999-06-15
Stucker, Jeffrey
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds virus or component thereof
53038835, 4242081, 435 5, A61K 3942, A61K 3921, C12Q 170, C07K 1600
Patent
active
059119896
ABSTRACT:
Disclosed are antibodies which can be used for the manufacture of vaccines for active and/or passive immunization of persons in need of such treatment. The invention also provides for human monoclonal antibodies that are functionally equivalent to the above-mentioned antibodies produced by any one of the cell lines CL1 through CL6 (deposited at the European Collection of Animal Cell Cultures (ECACC) at the PHLS in Porton Down, Salisbury, UK). Also provided are hybridoma and/or CHO cell lines producing any one of the antibodies disclosed and claimed herein. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention and/or therapeutical treatment of HIV-1 infections in vitro and in vivo.
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Fahey et al., Status of immune-based therapies in HIV infection and Aids Clin. Exp. Immunol. (1992)88, 1-5, Jan. 1992.
Luckow et al., Trends in the development of Baculovirus expression vectors, Bio/Tech vol. 6, pp. 47-55, see Abstract and p. 47, column 1, sentence 4, Jan. 1988.
Ratner et al., Complete nucleotide sequence of the AIDS virus, HTLV-III, Nature 313:277-284, Jan. 1985.
Ballaun Claudia
Buchacher Andrea
Ernst Wolfgang
Katinger Hermann
Klima Annelies
Park Hankyel T.
Polynum Scientific Immunbiologische Forschung GmbH
Stucker Jeffrey
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