HIV targeted hairpin ribozymes

Details HIV targeted hairpin ribozymes HIV targeted hairpin ribozymes

1993-06-17

1999-02-02

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 245, 435 6, 435 9131, 4351723, 435199, 4352402, 4353201, 514 44, C12N 1554, C12N 1585, C12N 922, A61K 3170

Patent

active

058667016

ABSTRACT:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

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