Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-02-08
2005-02-08
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S359000, C514S367000, C514S393000, C514S412000, C514S415000, C514S451000, C514S460000, C548S152000, C548S169000, C548S178000, C548S304400, C548S509000, C549S029000, C549S292000, C549S417000
Reexamination Certificate
active
06852711
ABSTRACT:
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
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Vara Prasad, et al., “Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxmide-2-t-butyl, 5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties”,Bioorganic&Medicinal Chemistry Letters, vol. 9, No. 11, 1999, pp. 1481-1486.
Boyer, Jr. Frederick Earl
Domagala John Michael
Ellsworth Edmund Lee
Gajda Christopher Andrew
Hagen Susan Elizabeth
Agouron Pharmaceuticals , Inc.
Hutchinson Keith D.
Patel Sudhaker B.
Raymond Richard L.
Richardson Peter C.
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