HIV protease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S359000, C514S367000, C514S393000, C514S412000, C514S415000, C514S451000, C514S460000, C548S152000, C548S169000, C548S178000, C548S304400, C548S509000, C549S029000, C549S292000, C549S417000

Reexamination Certificate

active

06852711

ABSTRACT:
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

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Hagen, et al., “Synthesis of 5,6-Dihydro-4-hydroxy-2-pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity”,J. Med. Chem., vol. 40, No. 23, 1997, pp. 3707-3711.
Ellsworth, et al., “4-hydroxy-5,6-dihydro-2H-pyran-2-ones. 3. Bicyclic and heteroaromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme”,Bioorganic&Medicinal Chemical Letters, vol. 9, No. 14, 1999, pp. 2019-2024.
Vara Prasad, et al., “Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxmide-2-t-butyl, 5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties”,Bioorganic&Medicinal Chemistry Letters, vol. 9, No. 11, 1999, pp. 1481-1486.

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