Highly selective inhibitors of the urokinase plasminogen...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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Details

C514S534000, C514S563000, C514S620000

Reexamination Certificate

active

07049344

ABSTRACT:
A method is described for inhibiting urokinase plasminogen activator in a human or animal patient. The method involves administering to the patient a urokinase plasminogen activator inhibiting effective amount of a compound of the formula (I):

REFERENCES:
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patent: 6248738 (2001-06-01), Dickinson et al.
patent: 6534546 (2003-03-01), Honda et al.
patent: WO 99 20608 (1999-04-01), None
patent: WO 00 04954 (2000-02-01), None
patent: WO 01 14324 (2001-03-01), None
S. Sperl et al., “(4-Aminomethyl)phenylguanidine Derivatives As Nonpeptidic Highly Selective Inhibitors of Human Urokinase,” Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, US, vol. 97, No. 10, May 9, 2000, pp. 5113-5118, XP002169711.
R. Rai et al., “Guanidinophenyl-Substituted Enol Lactones As Selective Mechanism-Based Inhibitors of Trypsin-Like Serine Proteases,” Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 35, No. 22, 1992, pp. 4150-4159, XP000978771.
Y, Heechung et al., “Selective Inhibition of Urokinase By Substituted Phenylguanidines: Quantitative Structure-Activity Relationship Analyses,” Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 33, No. 11, 1990, pp. 2956-2961, XP002059264.

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