Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1997-08-19
1999-06-08
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514283, 546 14, 546 48, 544238, C07D49122
Patent
active
059104910
ABSTRACT:
Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
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Haridas Kochat
Hausheer Frederick H.
Murali Dhanabalan
Petluru Pavankumar N.V.
Reddy Dasharatha
BioNumerik Pharmaceuticals, Inc.
Daus Donald G.
Dodd Thomas J.
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