Highly concentrated TCF pharmaceutical preparations

Details Highly concentrated TCF pharmaceutical preparations Highly concentrated TCF pharmaceutical preparations

1994-02-18

1996-04-23

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514970, A61K 3817

Patent

active

055103278

ABSTRACT:
This invention provides pharmaceutical preparations containing highly concentrated tumor cytotoxic factor (TCF). The pharmaceutical preparations of the present invention contain highly concentrated TCF and a basic amino acid or their salts, or an organic or inorganic salt as a solubizer. The resultant compositions described in the present invention dissolve TCF at high concentrations of 10 mg/ml or over under about neutral and isotonic conditions. The resultant compositions are stable and are suitable for injection preparations.

REFERENCES:
patent: 4076701 (1978-02-01), Burton et al.
patent: 4481137 (1984-11-01), Ohnishi et al.
patent: 4650674 (1987-03-01), Aggarwal et al.
patent: 4777241 (1988-10-01), Irikura et al.
patent: 4822605 (1989-04-01), Powell
patent: 4870163 (1989-09-01), Rubin et al.
patent: 5328836 (1994-07-01), Shima et al.
K. Michael Weidner et al., "Evidence for the Identify of Human Scatter Factor and Human Hepatocyte Growth Factor", Proc. Natl. Acad. Sci. USA, 88:7001-7005 (1991).

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