Composite anesthetic article and method of use

Details Composite anesthetic article and method of use Composite anesthetic article and method of use

1991-01-02

1993-07-13

Rosenbaum, C. Fred

Surgery

Container for blood or body treating material, or means used...

Container with piercable closure

A61B 1900

Patent

active

052269019

ABSTRACT:
An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9, wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing sufficient NaHCO.sub.3 to maintain the pH thereof between about 7.0 and about 7.6, and further containing from about 0.0004 moles of dissolved CO.sub.2 per ml of composition up to the saturation level of dissolved CO.sub.2 at a CO.sub.2 head pressure of up to about 2.5 atmospheres.

REFERENCES:
patent: 3978212 (1976-08-01), Barna
patent: 4663166 (1987-05-01), Veech
patent: 4861592 (1989-08-01), Gottwald et al.
Condouris et al., "Potentiation of the Nerve--Depressant Effect of Local Anesthetics by CO.sub.2 " Nature, vol. 204, No. 4953, pp. 57-59, 1964.
Martin et al., "Effects of CO.sub.2 . . . " Canad. Anaesth. Soc. Jr., vol. 28, No. 3, May 1981, 224-227.
McKay et al., "Sodium Bicarbonate Attenuates Pain . . . " Anesth. Analg. vol. 66, pp. 572-574, 1987.

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