Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1996-09-16
1999-07-13
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424489, 514817, A61K 950, A61K 952, A61L 1564
Patent
active
059223405
ABSTRACT:
A formulation for inducing sustained local anesthesia in a patient comprising a substrate comprising a high load of local anesthetic by weight and an effective amount of a biocompatible, controlled release material to obtain a reversible nerve blockade or anesthesia effect when implanted or injected in a patient, and a non-toxic glucocorticosteroid agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the glucocorticosteroid agent.
REFERENCES:
patent: 2174796 (1939-10-01), Luzzi
patent: 2835628 (1958-05-01), Saffir
patent: 3185625 (1965-05-01), Brown
patent: 3337400 (1967-08-01), Smith
patent: 3507952 (1970-04-01), Rednick et al.
patent: 3535419 (1970-10-01), Siegrist et al.
patent: 3736646 (1973-06-01), Schmitt et al.
patent: 3755558 (1973-08-01), Scribner
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3844285 (1974-10-01), Laby
patent: 3887699 (1975-06-01), Yolles
patent: 3943063 (1976-03-01), Morishita et al.
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 3972999 (1976-08-01), Tsuk
patent: 3976071 (1976-08-01), Sadek
patent: 3991766 (1976-11-01), Schmitt et al.
patent: 4001388 (1977-01-01), Shell
patent: 4011312 (1977-03-01), Reuter et al.
patent: 4034758 (1977-07-01), Theeuwes
patent: 4039653 (1977-08-01), DeFoney et al.
patent: 4070347 (1978-01-01), Schmitt
patent: 4076798 (1978-02-01), Casey et al.
patent: 4089800 (1978-05-01), Temple
patent: 4093709 (1978-06-01), Choi et al.
patent: 4118470 (1978-10-01), Casey et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
patent: 4144317 (1979-03-01), Higuchi et al.
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4166107 (1979-08-01), Miller et al.
patent: 4166800 (1979-09-01), Fong
patent: 4175326 (1979-11-01), Goodson
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4250163 (1981-02-01), Nagai et al.
patent: 4276880 (1981-07-01), Malmin
patent: 4293539 (1981-10-01), Ludwig et al.
patent: 4321038 (1982-03-01), Porteous
patent: 4369172 (1983-01-01), Schor et al.
patent: 4384975 (1983-05-01), Fong
patent: 4389330 (1983-06-01), Tice et al.
patent: 4404183 (1983-09-01), Kawata et al.
patent: 4419340 (1983-12-01), Yolles
patent: 4434153 (1984-02-01), Urquhart et al.
patent: 4479911 (1984-10-01), Fong
patent: 4530840 (1985-07-01), Tice et al.
patent: 4542025 (1985-09-01), Tice et al.
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4568535 (1986-02-01), Loesche
patent: 4568536 (1986-02-01), Kronenthal et al.
patent: 4569837 (1986-02-01), Suzaki et al.
patent: 4585651 (1986-04-01), Beck et al.
patent: 4597960 (1986-07-01), Cohen
patent: 4622219 (1986-11-01), Haynes
patent: 4622244 (1986-11-01), Lapka et al.
patent: 4623588 (1986-11-01), Nuwayser et al.
patent: 4650665 (1987-03-01), Kronenthal et al.
patent: 4652441 (1987-03-01), Okada et al.
patent: 4685883 (1987-08-01), Jernberg
patent: 4713244 (1987-12-01), Bawa et al.
patent: 4716203 (1987-12-01), Casey et al.
patent: 4725442 (1988-02-01), Haynes
patent: 4735945 (1988-04-01), Sakamoto et al.
patent: 4756907 (1988-07-01), Beck et al.
patent: 4757128 (1988-07-01), Domb et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4780320 (1988-10-01), Baker
patent: 4789726 (1988-12-01), Hutchinson
patent: 4801739 (1989-01-01), Franz et al.
patent: 4861627 (1989-08-01), Mathiowitz et al.
patent: 4874612 (1989-10-01), Deasy
patent: 4882168 (1989-11-01), Casey et al.
patent: 4883666 (1989-11-01), Sabel et al.
patent: 4888176 (1989-12-01), Langer et al.
patent: 4891225 (1990-01-01), Langer et al.
patent: 4892736 (1990-01-01), Goodson
patent: 4906474 (1990-03-01), Langer et al.
patent: 4919939 (1990-04-01), Baker
patent: 4933182 (1990-06-01), Higashi et al.
patent: 5000886 (1991-03-01), Lawter et al.
patent: 5004602 (1991-04-01), Hutchinson
patent: 5007790 (1991-04-01), Shell
patent: 5013553 (1991-05-01), Southard et al.
patent: 5019379 (1991-05-01), Domb et al.
patent: 5019400 (1991-05-01), Gombotz et al.
patent: 5032384 (1991-07-01), Yeh et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5084267 (1992-01-01), Damani
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5114718 (1992-05-01), Damani
patent: 5122367 (1992-06-01), Ron et al.
patent: 5143661 (1992-09-01), Lawter et al.
patent: 5188837 (1993-02-01), Domb
patent: 5198220 (1993-03-01), Damani
patent: 5222529 (1993-06-01), Zoltan
patent: 5225441 (1993-07-01), Vogel et al.
patent: 5227165 (1993-07-01), Domb et al.
patent: 5236355 (1993-08-01), Brizzolara et al.
patent: 5252701 (1993-10-01), Jarrett et al.
patent: 5264207 (1993-11-01), Bommelaer et al.
patent: 5272139 (1993-12-01), Cary, Jr.
patent: 5330452 (1994-07-01), Zook
patent: 5401507 (1995-03-01), Lewis
patent: 5407609 (1995-04-01), Tice et al.
patent: 5492901 (1996-02-01), Fabunan
patent: 5540912 (1996-07-01), Roorda et al.
patent: 5543156 (1996-08-01), Roorda et al.
patent: 5618563 (1997-04-01), Berde et al.
patent: 5650173 (1997-07-01), Ramstack et al.
patent: 5654008 (1997-08-01), Herbert et al.
Berde, C.B., et al., "Sustained Release of Dibucaine from a Biodegradable Polymer Matrix: A Potential Method for Prolonged Neural Blockade", Abstracts of Scientific Papers, 1990 Annual Meeting, Amer. Soc. Anesthesiologists, 73:A776 (Sep. 1990).
Edelman, Elazer R., et al., "Optimization of release from magnetically controlled polymeric drug release devices", Biomaterials, 14(8):621-626 (1993).
Masters, et al., Abstract No. 94.3, "Prolonged Sciatic Nerve Blockade Using Sustained Release of Veratridine From a Biodegradable Polymer Matrix", Soc. Neurosic. Abstr., 18:200 (1992).
Fong, Jones W., et al., "Evaluation of biodegradable microspheres prepared by a solvent evaporation process using sodium oleate as emulsifier", Journal of Controlled Release, 3:119-130 (1986).
Fong, J.W., "Microencapsulation by Solvent Evaporation and Organic Phase Separation Processes,", pp. 81-108, chapter 5 from Controlled Release Systems: Fabrication Technology, Ed. Dean Hsieh, Ph.D., vol. 1 (1988).
Masters, David B., et al. , "Prolonged Regional Nerve Blockade by Controlled Release of Local Anesthesia from a Biodegradable Polymer Matrix", Anesthesiology, 79:340-346 (1993).
Miyazaki, S., et al., "External control of drug release: controlled release of insulin from a hydrophilic polymer implant by ultrasound irradiation in diabetic rats", J. Pharm. Pharmacol., 40:716-717 (1988).
Sate, T., et al., "Porous Biodegradable Microspheres for Controlled Drug Delivery. I. Assessment of Processing Conditions and Solvent Removal Techniques", Pharmaceutical Research, 5:21-30 (1988).
Schneider, Markus, M.D., et al., "A Preferential Inhibition of Impulses in C-fibers of the Rabbit Vagus Nerve by Veratridine, an Activator of Sodium Channels", Anesthesiology, 74:270-280 (1991).
Tice, Thomas R., et al., "Preparation of Injectable Controlled-Release Microcapsules by a Solvent-Evaporation Process", Journal of Controlled Release, 2:343-352 (1985).
Wakiyama Nacki, et al., "Preparation and Evaluation in Vitro and in Vivo of Polylactic Acid Microspheres containing Dibucaine", Chem. Pharm. Bull, 30:3719-3727 (1982).
Duncan, et al., "Treatment of Upper Extremity Reflex Sympathetic Dystrophy with Joint Stiffness Using Sympatholytic Bier Blocks and Manipulation" Orthopedics 11(6), pp. 883-886, (1988).
Flanagan, et al., "Intra-articular injection for pain relief in patients awating hip replacement", Ann. Royal Coll. Surg. Eng., vol. 70, pp. 156-157 (1988).
Glasser, et al., "The perioperative use of corticosteroids and bupivacaine in the management of lumbar disc disease", J. Neurosurg., vol. 78, pp. 383-387, (1993).
Guttu, et al., "Delayed Healing of Muscle After Injection of Bupivacaine and Steroid", Annals of Dentistry, 49:5-8, (1990).
Hall, et al., "Acute effects of intravenous glucocorticoid on cat spinal motor neuron electrical properties", Brain Research, vol. 240, pp. 186-190, (1982).
Sandrock and Warfield, "Epidural Steroids and Facet Injections", Ch. 29 Principles and Practice of Pain Management, Warfield, C.A., editor (McGraw-Hill, Inc. 1993).
Waldman, et al., "The Relief of Body Wall Pai
Berde Charles B.
Castillo Jenny
Curley Joanne
Langer Robert S.
Children's Medical Center Corporation
Kulkosky Peter F.
LandOfFree
High load formulations and methods for providing prolonged local does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with High load formulations and methods for providing prolonged local, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High load formulations and methods for providing prolonged local will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2273550