Hexapeptide anaphylatoxin-receptor ligands

Details Hexapeptide anaphylatoxin-receptor ligands Hexapeptide anaphylatoxin-receptor ligands

1990-12-27

1995-01-31

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530317, 530328, 530327, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

053860110

ABSTRACT:
Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.
Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

REFERENCES:
Swerlick et al., The Journal of Immunology, vol. 140, No. 7, Apr. 1988, pp. 2376-2381.
Mollison et al, PNAS, vol. 86, pp. 292-296, Jan. 1989.
Hartung et al., The Journal of Immunology, vol. 130, No. 3, Mar. 1983, pp. 1345-1349.
Kings et al., Immunology Letters, 8, 1984 pp. 23-25.
Kohl et al., Eur. J. Immunol., 1990, vol. 20, pp. 1463-1468.

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