Heterodimers forms of CSF-1 and pharmaceutical compositions ther

Details Heterodimers forms of CSF-1 and pharmaceutical compositions ther Heterodimers forms of CSF-1 and pharmaceutical compositions ther

1994-11-04

1997-07-29

Jagannathan, Vasu

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 695, 930145, A61K 3819, C07K 1453, C12N 1527

Patent

active

056519630

ABSTRACT:
The present invention relates to the production of CSF-1 heterodimers and pharmaceutical formulations of the heterodimers. The heterodimers can be formed using CSF-1 monomers that have variations in sequence, N or C-terminal processing. For example, CSF/C.gradient.150 can be dimerized with LCSF/C.gradient. 190 to form a heterodimer. Dimerization may occur by separately preparing homodimers and mixing them together under the appropriate conditions. Thereafter, homodimers may be separated from the heterodimers by various chromatographic techniques. Once the heterodimers are isolated, pharmaceutical preparations can be prepared.

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