Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1992-12-04
1994-02-08
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 95, 514 99, 514903, 549 8, 549218, A61K 31685, A61K 3167
Patent
active
052848361
ABSTRACT:
The invention discloses certain heterocyclic, thioether, keto-ester and alkyl phospholipids, e.g., heterocyclic phospholipids having the formula ##STR1## where R is n-C.sub.14 -C.sub.20 alkyl or O-n-C.sub.14 -C.sub.20 alkyl; each R.sub.1 is methyl or ethyl; n is 2-6; and X is --CH.sub.2 --m, where m is 2-4, CH.sub.2 CH.sub.2 O or CH.sub.2 CH.sub.2 S, or a corresponding hydrate thereof, which compounds are useful in treating multiple sclerosis.
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patent: 4673672 (1987-06-01), Houlihan et al.
patent: 4749696 (1988-06-01), Lee
patent: 4778788 (1988-10-01), Munder
patent: 5049552 (1991-09-01), Eibl
E. Bosies et al., Lipids, vol. 22, pp. 947-951 (1987).
I. Kudo, et al. Lipids, vol. 22, pp. 862-867 (1987).
Borovian Joseph J.
Criares T. J.
Honor Robert S.
Kassenoff Melvyn M.
Sandoz Ltd.
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