Heterocyclic compounds and their production

Details Heterocyclic compounds and their production Heterocyclic compounds and their production

1991-04-12

1993-07-27

Waddell, Frederick E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548229, 548230, C07D20500, C07D26304, C07D26338, C07D41306

Patent

active

052311791

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R.sub.1 and R.sub.2 may be combined together to form a lower alkylene group and/or R.sub.3 and R.sub.4 are combined together to form a lower alkylene group, or R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1.beta.-methylcarbapenem compounds valuable as antibiotics.

REFERENCES:
Shib et al., "Synthetic Carbapenem Antibiotics . . . ," Heterocycles, vol. 21, No. 1, 1984, pp. 22-44.
Oida et al. "Synthetic Approach Directed at 1-Carbopenams . . . ," Chem. Pharm. Bull., vol. 28, No. 12, 1980, pp. 3494-3500.
Abdel-Magid et al, J. Am. Chem. Soc. 1986, 108, 4595-4602.
Nagao et al, J. Am. Chem. Soc. 1986, 108, 4673-4675.
Evans I: CA 103:37401(c), 1985.
Evans II: CA 108:112900y, 1987.
Evans III: CA 107:237279p, 1987.
Evans IV: CA 108:150929x, 1987.
Aliev, Khim. Getero. Soed. (English language version), v. 3, No. 3, pp. 341-342 (1967).

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