Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-08-21
1998-03-31
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514304, 546112, 546126, A61K 3146, A61K 3147, C07D45106, C07D45104
Patent
active
057339171
ABSTRACT:
1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): ##STR1## or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.
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Talley, N.J., Review Article: 5-hydroxytryptamine agonists . . . , Alimentary Pharmacology & Therapeutics, vol. 6, p. 273, 1992.
Dumis, Aline, et al, A Nonclassical 5-Hydroxytryptamine Receptor . . . , Molecular Pharmacology, vol. 34, p. 880, 1988.
Molecular Pharmacology, 34: 880-887, 1988, A Nonclassical 5-Hydroxytryptamine Receptor Positively Coupled with Adenylate Cyclase in the Central Nervous System, Aline Dumuis et al.
Aliment. Pharmacol. Ther. (1992) 6, 273-289, Review Article: 5-Hydroxytryptamine Agonists and Antagonists in the Modulation of Gastrointestinal Motility and Sensation: Clinical Implications, N.J. Talley.
Asanuma Hajime
Hatayama Katsuo
Isobe Yoshihiko
Kijima Haruko
Muramatsu Makoto
Gupta Yogendra N.
Qazi Sabiha N.
Taisho Pharmaceutical Co. Ltd.
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