Heterocyclic bisphosphonic acid derivatives

Details Heterocyclic bisphosphonic acid derivatives Heterocyclic bisphosphonic acid derivatives

1991-10-25

1992-07-07

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 92, 546 22, 548111, A61K 31675, C07F 906, C07F 928

Patent

active

051283280

ABSTRACT:
The compound of the formula: ##STR1## positioned so that the gem-diphosphonic acid carbon atom is in the 4- or 5-position; R.sup.1 is alkyl or arylalkyl; R.sup.2 is hydrogen, 2- or 3-pyridinyl or 3-,5- or 6-alkylpyridin-2-yl; or a pharmaceutically acceptable salt thereof, with the proviso that when the gem-bisphosphonic acid substituted carbon atom is in 4-position, R.sup.1 is other than alkyl, used in the treatment of disease states involving calcium metabolism.

REFERENCES:
patent: 4503049 (1985-03-01), Biere et al.

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