Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-07-05
2011-07-05
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S391000, C548S321500
Reexamination Certificate
active
07973067
ABSTRACT:
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, whereinW is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—;X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—;U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond;and R1, R2, R3, R4, R5, R6, and R7are as defined in the specification;and pharmaceutical compositions comprising the compounds of formula I.Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1agonist or m2antagonist.
REFERENCES:
patent: 5338740 (1994-08-01), Carpino et al.
patent: 5391560 (1995-02-01), Fuchs et al.
patent: 5534520 (1996-07-01), Fisher et al.
patent: 5731431 (1998-03-01), Nakagawa et al.
patent: 5852029 (1998-12-01), Fisher et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5889006 (1999-03-01), Lowe et al.
patent: 5935958 (1999-08-01), Kozlowski et al.
patent: 5952349 (1999-09-01), Asberom et al.
patent: 5977138 (1999-11-01), Wang et al.
patent: 6037352 (2000-03-01), Lowe et al.
patent: 6043255 (2000-03-01), Lowe et al.
patent: 6066636 (2000-05-01), Kozlowski et al.
patent: 6087509 (2000-07-01), Claussner et al.
patent: 6294554 (2001-09-01), Clader et al.
patent: 6344473 (2002-02-01), Hansen, Jr. et al.
patent: 6458812 (2002-10-01), McKittrick et al.
patent: 6713276 (2004-03-01), Cordell et al.
patent: 7183070 (2007-02-01), Cordell et al.
patent: 7354933 (2008-04-01), Patek et al.
patent: 7417047 (2008-08-01), Malamas et al.
patent: 7423158 (2008-09-01), Malamas et al.
patent: 7482349 (2009-01-01), Malamas et al.
patent: 2002/0143024 (2002-10-01), Murugesan et al.
patent: 2004/0248884 (2004-12-01), Patek et al.
patent: 2005/0171112 (2005-08-01), Schultz et al.
patent: 2005/0282825 (2005-12-01), Malamas et al.
patent: 2005/0282826 (2005-12-01), Malamas et al.
patent: 2006/0034848 (2006-02-01), Kinoshita et al.
patent: 2006/0111370 (2006-05-01), Zhu et al.
patent: 2007/0004730 (2007-01-01), Zhou et al.
patent: 2007/0004786 (2007-01-01), Malamas et al.
patent: 2007/0027199 (2007-02-01), Malamas et al.
patent: 2007/0072852 (2007-03-01), Zhu et al.
patent: 2007/0072925 (2007-03-01), Malamas et al.
patent: 2007/0099875 (2007-05-01), Zhu et al.
patent: 2007/0203116 (2007-08-01), Quagliato et al.
patent: 2007/0232642 (2007-10-01), Baxter et al.
patent: 2007/0259898 (2007-11-01), Baxter et al.
patent: 2007/0287692 (2007-12-01), Wu et al.
patent: 2007/0299087 (2007-12-01), Berg et al.
patent: 2008/0051420 (2008-02-01), Berg et al.
patent: 2008/0058349 (2008-03-01), Berg et al.
patent: 2008/0108654 (2008-05-01), Patek et al.
patent: 2008/0161269 (2008-07-01), Berg et al.
patent: 2008/0200445 (2008-08-01), Zhu et al.
patent: 2008/0214577 (2008-09-01), Berg et al.
patent: 2008/0287460 (2008-11-01), Burrows et al.
patent: 2008/0287462 (2008-11-01), Chessari et al.
patent: 2009/0023762 (2009-01-01), Berg et al.
patent: 2009/0062282 (2009-03-01), Albert et al.
patent: 2009/0209529 (2009-08-01), Andreini et al.
patent: 36 43 890 (1988-06-01), None
patent: 0231919 (1987-12-01), None
patent: 0361341 (1990-04-01), None
patent: 0 591 781 (1994-04-01), None
patent: 0763054 (1997-03-01), None
patent: 0969011 (2000-01-01), None
patent: 1942105 (2006-07-01), None
patent: 11-335518 (1999-12-01), None
patent: WO89/03842 (1989-05-01), None
patent: WO90/04917 (1990-05-01), None
patent: WO 93/13064 (1993-07-01), None
patent: WO 93/23040 (1993-11-01), None
patent: WO 93/23041 (1993-11-01), None
patent: WO 95/03303 (1995-02-01), None
patent: WO 97/19064 (1997-05-01), None
patent: WO 97/45417 (1997-12-01), None
patent: WO 98/04525 (1998-02-01), None
patent: WO 99/05131 (1999-02-01), None
patent: WO01/07440 (2001-02-01), None
patent: WO 01/44239 (2001-06-01), None
patent: WO02/02512 (2002-01-01), None
patent: WO02/02518 (2002-01-01), None
patent: WO02/02520 (2002-01-01), None
patent: WO02/12243 (2002-02-01), None
patent: WO02/074719 (2002-09-01), None
patent: WO02/088101 (2002-11-01), None
patent: WO03/031412 (2003-04-01), None
patent: WO03/035613 (2003-05-01), None
patent: WO03/106405 (2003-12-01), None
patent: WO 2004/058727 (2004-07-01), None
patent: WO 2004/070050 (2004-08-01), None
patent: WO2005/013020 (2005-02-01), None
patent: WO2005/014540 (2005-02-01), None
patent: WO2005/016876 (2005-02-01), None
patent: WO2005/058311 (2005-06-01), None
patent: WO2005/097767 (2005-10-01), None
patent: WO2005/103020 (2005-11-01), None
patent: WO2005/103043 (2005-11-01), None
patent: WO2005/108391 (2005-11-01), None
patent: WO2005/113484 (2005-12-01), None
patent: WO2006/002004 (2006-01-01), None
patent: WO2006/009653 (2006-01-01), None
patent: WO2006/009655 (2006-01-01), None
patent: WO2006/014762 (2006-02-01), None
patent: WO2006/014944 (2006-02-01), None
patent: WO2006/017836 (2006-02-01), None
patent: WO 2006/017836 (2006-02-01), None
patent: WO2006/017844 (2006-02-01), None
patent: WO 2006/017844 (2006-02-01), None
patent: WO2006/024932 (2006-03-01), None
patent: WO 2006/024932 (2006-03-01), None
patent: WO2006/041404 (2006-04-01), None
patent: WO2006/041405 (2006-04-01), None
patent: WO2006/044497 (2006-04-01), None
patent: WO2006/065277 (2006-06-01), None
patent: WO2006/076284 (2006-07-01), None
patent: WO 2006/076284 (2006-07-01), None
patent: WO2006/138192 (2006-12-01), None
patent: WO2006/138195 (2006-12-01), None
patent: WO2006/138217 (2006-12-01), None
patent: WO2006/138230 (2006-12-01), None
patent: WO2006/138264 (2006-12-01), None
patent: WO2006/138265 (2006-12-01), None
patent: WO2006/138266 (2006-12-01), None
patent: WO2007/005366 (2007-01-01), None
patent: WO2007/005404 (2007-01-01), None
patent: WO2007/016012 (2007-02-01), None
patent: WO2007/038271 (2007-04-01), None
patent: WO 2007/049532 (2007-05-01), None
patent: WO 2007/050612 (2007-05-01), None
patent: WO2007/050721 (2007-05-01), None
patent: WO2007/053506 (2007-05-01), None
patent: WO2007/058580 (2007-05-01), None
patent: WO2007/058582 (2007-05-01), None
patent: WO2007/058583 (2007-05-01), None
patent: WO2007/058601 (2007-05-01), None
patent: WO2007/058602 (2007-05-01), None
patent: WO2007/073284 (2007-06-01), None
patent: WO2007/078813 (2007-07-01), None
patent: WO 2007/092839 (2007-08-01), None
patent: WO 2007/092846 (2007-08-01), None
patent: WO 2007/092854 (2007-08-01), None
patent: WO2007/100536 (2007-09-01), None
patent: WO2007/114771 (2007-10-01), None
patent: WO 2007/114771 (2007-10-01), None
patent: WO2007/145568 (2007-12-01), None
patent: WO2007/145569 (2007-12-01), None
patent: WO2007/145570 (2007-12-01), None
patent: WO2007/145571 (2007-12-01), None
patent: WO2007/146225 (2007-12-01), None
patent: WO2007/149033 (2007-12-01), None
patent: WO 2007/149033 (2007-12-01), None
patent: WO2008/022024 (2008-02-01), None
patent: WO 2008/022024 (2008-02-01), None
patent: WO2008/063114 (2008-05-01), None
patent: WO2008/073
Babu Suresh D.
Caldwell John P.
Cumming Jared N.
Greenlee William J.
Gu Huizhong
Devlin Gerard M.
Leeser Erich A
MacMillan Keith D.
Schering Corporation
Wilson James O
LandOfFree
Heterocyclic aspartyl protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclic aspartyl protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic aspartyl protease inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2712497