Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-07-12
1995-11-21
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514183, 514212, 5142328, 514291, 514293, 540481, 540597, 546 80, 546 83, 544126, 544361, A61K 3144, A61K 31495, C07D49514, C07D49504
Patent
active
054687500
ABSTRACT:
A compound of formula ##STR1## in which A represents S;
R.sub.1 is selected from the group consisting of OH, (C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy, benzyloxy, phenyl, benzyl (C.sub.1 -C.sub.4)alkyl NZ.sub.1 Z.sub.2, and NZ.sub.1 Z.sub.2 ;
R.sub.2 is selected from the group consisting of OH, SH, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, and NZ.sub.1 Z.sub.2 ;
R.sub.3 is selected from the group consisting of H, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkoxy, phenyl, and benzyl;
B is selected from the group consisting of phenyl; pyridyl; phenyl substituted by one or more groups selected from halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, CF.sub.3, CH.sub.2 NZ.sub.1 Z.sub.2, and NZ.sub.1 Z.sub.2 wherein Z.sub.1 and Z.sub.2 are selected, independently of each other, from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, formyl, and benzyl or --NZ.sub.1 Z.sub.2 is selected from the group consisting of pyrrolidinyl, piperidinyl, morpholino, hexahydroazepino, ##STR2## piperazino, piperazino substituted in position 4 by (C.sub.1 -C.sub.8)alkyl, benzyl or diphenylmethyl; and pyridyl substituted by one or more groups selected from halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, CF.sub.3, CH.sub.2 NZ.sub.1 Z.sub.2, and NZ.sub.1 Z.sub.2 wherein Z.sub.1 and Z.sub.2 are selected, independently of each other, from the group consisting of H, (C.sub.1 -C.sub.6)alkyl, formyl, and benzyl, or NZ.sub.1 Z.sub.2 is selected from the group consisting of pyrrolidinyl, piperidinyl, morpholino, hyxahydroazepino, ##STR3## piperazino, and piperazino substituted in position 4 by (C.sub.1 -C.sub.8)alkyl, benzyl or diphenylmethyl; or its salt with an acid or a base.
REFERENCES:
J. M. Barker et al., "Thienopyridines. Part 4. Preparation of Some Dithieno(3,2-bi:2i, 3i-d)pyridine Derivatives", Chemical Abstracts, vol. 97, 1982, Abs. No. 144802p, p. 683.
J. M. Barker et al., "Thienopyridines. Part 6. Synthesis & Nucleophilic Substitution of Some Chlorothieno(2,3-b)pyridine . . . ", Chemical Abstracts, vol. 104, 1986, Abs. No. 5801n, p. 5797.
J. Sharada et al., "Synthesis & Biological Activity of Furoquinolines: 2-Aroyl-4-methyl/4,6-dimethyl-3-phenylfuro(3,2-c)quinolines", Chemical Abstracts, vol. 108, 1988, Abs. No. 21749q, p. 587.
Bachy Andre
Fraisse Laurent
Keane Peter
Mendes Etienne
Simiand Jacques
Elf Sanofi
Henley III Raymond
Spivack Phyllis G.
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