Heteroaryl-ureas and their use as glucokinase activators

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S369000

Reexamination Certificate

active

07851636

ABSTRACT:
This invention relates to compounds of formula (I)which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

REFERENCES:
patent: 3067250 (1962-12-01), Oja
patent: 3152136 (1964-10-01), Harris et al.
patent: 3317534 (1967-05-01), Nitta et al.
patent: 3551442 (1970-12-01), Guillot et al.
patent: 3734923 (1973-05-01), Dowding et al.
patent: 3862163 (1975-01-01), Boroschewski et al.
patent: 3874873 (1975-04-01), Volpp et al.
patent: 3887709 (1975-06-01), Brzozowski et al.
patent: 3967950 (1976-07-01), Kano et al.
patent: 4153710 (1979-05-01), Brzozowski et al.
patent: 4160833 (1979-07-01), Diel
patent: 4174398 (1979-11-01), Regel et al.
patent: 4175081 (1979-11-01), Driscoll
patent: 4183856 (1980-01-01), Makisumi et al.
patent: 4241072 (1980-12-01), Bolhofer
patent: 4243404 (1981-01-01), Kruger et al.
patent: 4405644 (1983-09-01), Kabbe et al.
patent: 4694004 (1987-09-01), Nakaguti et al.
patent: 4808722 (1989-02-01), Henrie, II
patent: 5262415 (1993-11-01), Takemoto et al.
patent: 5371086 (1994-12-01), Takemoto et al.
patent: 5556969 (1996-09-01), Chambers et al.
patent: 5846985 (1998-12-01), Murugesan
patent: 5846990 (1998-12-01), Murugesan et al.
patent: 5849732 (1998-12-01), Suzuki et al.
patent: 5849769 (1998-12-01), Lind et al.
patent: 5891917 (1999-04-01), Tang et al.
patent: 5935993 (1999-08-01), Tang et al.
patent: 6001860 (1999-12-01), Hamanaka
patent: 6140343 (2000-10-01), DeNinno et al.
patent: 6180635 (2001-01-01), Cheshire et al.
patent: 6225346 (2001-05-01), Tang et al.
patent: 6268384 (2001-07-01), Novak et al.
patent: 6271248 (2001-08-01), Murugesan et al.
patent: 6384220 (2002-05-01), Corbett et al.
patent: 6448290 (2002-09-01), Ohuchida et al.
patent: 6486184 (2002-11-01), Kester et al.
patent: 6489478 (2002-12-01), DeNinno et al.
patent: 6500817 (2002-12-01), Fischer et al.
patent: 6559168 (2003-05-01), Marfat et al.
patent: 6608218 (2003-08-01), Kester et al.
patent: 6720347 (2004-04-01), Rawlins et al.
patent: 6720427 (2004-04-01), Sanner et al.
patent: 6784198 (2004-08-01), Pevarello et al.
patent: 6863647 (2005-03-01), Pevarello et al.
patent: 6875760 (2005-04-01), Lau et al.
patent: 6903125 (2005-06-01), Kontani et al.
patent: 6916814 (2005-07-01), Moss et al.
patent: 6936629 (2005-08-01), Chan Chun Kong et al.
patent: 7056942 (2006-06-01), Hildesheim et al.
patent: 7196104 (2007-03-01), Askew et al.
patent: 7384967 (2008-06-01), Polisetti et al.
patent: 7582769 (2009-09-01), Murray et al.
patent: 2002/0198200 (2002-12-01), Kester et al.
patent: 2003/0171411 (2003-09-01), Kodra et al.
patent: 2003/0220350 (2003-11-01), Lau et al.
patent: 2004/0014789 (2004-01-01), Lau et al.
patent: 2004/0014968 (2004-01-01), Bizzarro et al.
patent: 2007/0054897 (2007-03-01), Murray et al.
patent: 2009/0216013 (2009-08-01), Murray et al.
patent: 2416229 (2007-09-01), None
patent: 100506807 (2009-07-01), None
patent: 1901501 (1969-08-01), None
patent: 2040580 (1971-04-01), None
patent: 2117807 (1971-10-01), None
patent: 2129418 (1971-12-01), None
patent: 29937 (1972-12-01), None
patent: 2228890 (1972-12-01), None
patent: 2151766 (1973-04-01), None
patent: 2431801 (1975-01-01), None
patent: 2264983 (1975-10-01), None
patent: 2712630 (1978-09-01), None
patent: 0129408 (1984-12-01), None
patent: 432040 (1997-12-01), None
patent: 885890 (1998-12-01), None
patent: 1211246 (2002-06-01), None
patent: 1169312 (2004-10-01), None
patent: 979823 (2006-03-01), None
patent: 2001083 (1969-09-01), None
patent: 7428 (1969-12-01), None
patent: 2215967 (1974-08-01), None
patent: 771147 (1957-03-01), None
patent: 1185540 (1970-03-01), None
patent: 1195672 (1970-06-01), None
patent: 1282308 (1972-07-01), None
patent: 1318291 (1973-05-01), None
patent: 01056660 (1989-03-01), None
patent: 64056660 (1989-03-01), None
patent: 4334374 (1992-11-01), None
patent: 6016621 (1994-01-01), None
patent: 6102611 (1994-04-01), None
patent: 2002-536056 (2002-10-01), None
patent: 2021258 (1994-10-01), None
patent: WO9104027 (1991-04-01), None
patent: WO 93/24458 (1993-12-01), None
patent: WO9414801 (1994-07-01), None
patent: WO 97/24328 (1997-07-01), None
patent: WO 99/24035 (1999-05-01), None
patent: WO 99/24416 (1999-05-01), None
patent: WO 99/32106 (1999-07-01), None
patent: WO 99/32111 (1999-07-01), None
patent: WO9962890 (1999-12-01), None
patent: WO0017165 (2000-03-01), None
patent: WO 00/26186 (2000-05-01), None
patent: WO0026203 (2000-05-01), None
patent: WO 00/45742 (2000-08-01), None
patent: WO0053591 (2000-09-01), None
patent: WO0058293 (2000-10-01), None
patent: WO 01/00206 (2001-04-01), None
patent: WO0144216 (2001-06-01), None
patent: WO0144217 (2001-06-01), None
patent: WO 01/57008 (2001-08-01), None
patent: WO 01/83478 (2001-11-01), None
patent: WO0183465 (2001-11-01), None
patent: WO0185706 (2001-11-01), None
patent: WO185707 (2001-11-01), None
patent: WO0208209 (2002-01-01), None
patent: WO 02/14311 (2002-02-01), None
patent: WO 02/46173 (2002-06-01), None
patent: 0200396 (2002-07-01), None
patent: WO 02/070494 (2002-09-01), None
patent: WO03055482 (2002-12-01), None
patent: WO 03/055482 (2003-07-01), None
patent: WO 03/070727 (2003-08-01), None
patent: WO04002481 (2004-01-01), None
patent: WO04085388 (2004-10-01), None
patent: WO05066145 (2005-07-01), None
patent: WO05103050 (2005-11-01), None
patent: WO 2007/006814 (2007-01-01), None
patent: WO 2008/084043 (2008-07-01), None
patent: WO 2008/084044 (2008-07-01), None
National Institutes of Health Consensus, Ann. Int. Med., vol. 103, pp. 147-151, 1985.
Mann, G.V., N. Eng. J. Med., vol. 291(5), pp. 226-232, 1974.
U.S. Appl. No. 11/994,728, filed Jan. 2008 Murray.
U.S. Appl. No. 12/188,402, filed Aug. 2008, Murray.
U.S. Appl. No. 60/879,683, filed Jan. 2007 Murray.
U.S. Appl. No. 60/879,961, filed Jan. 2007 Murray.
Colowick, S.P., The Hexokinases, The Enzymes, vol. 9, pp. 1-48, 1973.
Chipkin, S.R. et al., Joslin's Diabetes, pp. 97-115, 1994.
Printz, R.L. et al., Annual Review of Nutrition, vol. 13, pp. 463-496, 1993.
Meglasson, M.D. et al., American Journal of Physiology, vol. 246, pp. E1-E13, 1984.
Grupe, A. et al., Cell, vol. 83, pp. 69-78, 1995.
Ferre, T. et al., The Faseb Journal, vol. 10, pp. 1213-1218, 1996.
Liang, Y. et al., Biochem Journal, vol. 309, p. 167-173, 1995.
Glaser, B. et al., The New England Journal of Medicine, vol. 338, pp. 226-230, 1998.
Grassie, V.R. et al., Canadian Journal Research, vol. 28B, pp. 468-484, 1950.
Gardner, J.A.F., Canadian Journal Research, vol. 26B, pp. 681,693, 1948.
Decombe, J. et al., Annual of Chem App., vol. 18, pp. 81-187, 1932.
Sovetskaya Enthiklopedia, pp. 130-131, 1983.
Girard et al., Annual Review of Nutrition, vol. 17, pp. 325-352, 1997.
Office Action from the European Patent Office dated Oct. 17, 2006.
Wolff Burger's Medical Chemistry and Drug Discovery, vol. 1, Principles and Practice, pp. 172-178, 1995.
Castelhano, A.L. et al., Bioorg & med Chemistry Letters, vol. 15, pp. 1501-150, 2005.
Atwal et al., 1996, “Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers 4 Structure-Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion,” Journal of Medicinal Chemistry 39:304-313.
Evans, et al., 1986, “Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, No. 13, Juillet 1986, USA pp. 4918-4922 (corresponds to EP0432040, previously cited).
Goerdeler et al., 1980, “Acylcarbodiimides. IV. Preparation and Some Reactions of Carbamoylcarboiimides,” Hcaplus, Accession No. 585914.
Heitmeier et al., 1964, “Hydroxyphenethylamino Derivatives of Various Nitrogen Heterocycles,” Journal of Medicinal Chemistry 7(3):288-293.
Mylari et al., 2003, “Design and Synthesis of a Novel Family of Triazine-Based Inhibitors of Sorbitol Dehydrogenase with Oral Activity: 1-{4- [3R,5S-Dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heteroaryl-ureas and their use as glucokinase activators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heteroaryl-ureas and their use as glucokinase activators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroaryl-ureas and their use as glucokinase activators will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4211649

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.