Heteroaryl antagonists of prostaglandin D 2 receptors

Details Heteroaryl antagonists of prostaglandin D 2 receptors Heteroaryl antagonists of prostaglandin D 2 receptors

2009-09-28

2011-11-01

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S290000, C546S286000, C514S344000, C514S357000

Reexamination Certificate

active

08049015

ABSTRACT:
Described herein are compounds that are antagonists of PGD2receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

REFERENCES:
patent: 5239084 (1993-08-01), Philippe et al.
patent: 5334598 (1994-08-01), Bagley et al.
patent: 5668176 (1997-09-01), Bagley et al.
patent: 5827868 (1998-10-01), Misra et al.
patent: 6028080 (2000-02-01), Ackermann et al.
patent: 6617351 (2003-09-01), Arnold et al.
patent: 6884593 (2005-04-01), Hirai et al.
patent: 7144913 (2006-12-01), Wang et al.
patent: 7205329 (2007-04-01), Chien et al.
patent: 2001/0047027 (2001-11-01), Labelle et al.
patent: 2002/0198251 (2002-12-01), Sundermann et al.
patent: 2004/0214888 (2004-10-01), Matsuura et al.
patent: 2005/0154044 (2005-07-01), Beaulieu et al.
patent: 2005/0171143 (2005-08-01), Tanimoto et al.
patent: 2005/0272756 (2005-12-01), Leblanc et al.
patent: 2006/0100425 (2006-05-01), Bennani et al.
patent: 2006/0106081 (2006-05-01), Bennani et al.
patent: 2008/0167378 (2008-07-01), Fukatsu et al.
patent: 2008/0306109 (2008-12-01), Hynd et al.
patent: 2009/0186923 (2009-07-01), Armer et al.
patent: 2009/0197959 (2009-08-01), Hutchinson et al.
patent: 2010/0004331 (2010-01-01), Hutchinson et al.
patent: 2010/0081673 (2010-04-01), Hutchinson et al.
patent: 2010/0113503 (2010-05-01), Hutchinson et al.
patent: 2010/0173313 (2010-07-01), Bain et al.
patent: 2010/0280049 (2010-11-01), Stearns et al.
patent: 2010/0298368 (2010-11-01), Stearns et al.
patent: 2011/0021573 (2011-01-01), Hutchinson et al.
patent: 2011/0034558 (2011-02-01), Brittain et al.
patent: 2011/0039852 (2011-02-01), Hutchinson et al.
patent: 1170594 (2002-01-01), None
patent: 2460597 (2010-04-01), None
patent: 2461629 (2010-05-01), None
patent: 2463788 (2010-12-01), None
patent: 2004-182657 (2004-07-01), None
patent: WO-95-03044 (1995-02-01), None
patent: WO-99-11605 (1999-03-01), None
patent: WO-03-006011 (2003-01-01), None
patent: WO-2003-062200 (2003-07-01), None
patent: WO-2004-035543 (2004-04-01), None
patent: WO-2004-058164 (2004-07-01), None
patent: WO-2004-096777 (2004-11-01), None
patent: WO-2005-019161 (2005-03-01), None
patent: WO-2005-040114 (2005-05-01), None
patent: WO-2005-044260 (2005-05-01), None
patent: WO-2005-051373 (2005-06-01), None
patent: WO-2005-100298 (2005-10-01), None
patent: WO-2006-002099 (2006-01-01), None
patent: WO-2006-005909 (2006-01-01), None
patent: WO-2006-014357 (2006-02-01), None
patent: WO-2006-015158 (2006-02-01), None
patent: WO-2006-037982 (2006-04-01), None
patent: WO-2006-044732 (2006-04-01), None
patent: WO-2006-052798 (2006-05-01), None
patent: WO-2006-053791 (2006-05-01), None
patent: WO-2006-056854 (2006-06-01), None
patent: WO-2006-070325 (2006-07-01), None
patent: WO-2006-090915 (2006-08-01), None
patent: WO-2006-091496 (2006-08-01), None
patent: WO-2006-125596 (2006-11-01), None
patent: WO-2007-024922 (2007-03-01), None
patent: WO-2007-037187 (2007-04-01), None
patent: WO-2007-039736 (2007-04-01), None
patent: WO-2007-068894 (2007-06-01), None
patent: WO-2007-088996 (2007-08-01), None
patent: WO-2007-107772 (2007-09-01), None
patent: WO-2007-144127 (2007-12-01), None
patent: WO-2008-017989 (2008-02-01), None
patent: WO-2008-024746 (2008-02-01), None
patent: WO-2008-033455 (2008-03-01), None
patent: WO-2008-082567 (2008-07-01), None
patent: WO-2008-137027 (2008-11-01), None
patent: WO-2008-156780 (2008-12-01), None
patent: WO-2009-004379 (2009-01-01), None
patent: WO-2009-044147 (2009-04-01), None
patent: WO-2009-063202 (2009-05-01), None
patent: WO-2009-063215 (2009-05-01), None
patent: WO-2009-089192 (2009-07-01), None
patent: WO-2009-099901 (2009-08-01), None
patent: WO-2009-099902 (2009-08-01), None
patent: WO-2009-102893 (2009-08-01), None
patent: WO-2009-108720 (2009-09-01), None
patent: WO-2009-145989 (2009-12-01), None
patent: WO-2010-003120 (2010-01-01), None
patent: WO-2010-003120 (2010-01-01), None
patent: WO-2010-003127 (2010-01-01), None
patent: WO-2010-037054 (2010-04-01), None
patent: WO-2010-037059 (2010-04-01), None
patent: WO-2010-039977 (2010-04-01), None
patent: WO-2010-042652 (2010-04-01), None
patent: WO-2010-057118 (2010-05-01), None
patent: WO-2011-014587 (2011-02-01), None
patent: WO-2011-014588 (2011-02-01), None
patent: WO-2011-017201 (2011-02-01), None
Srinivas et al., “Biaryl amino acid templates in place of D-Pro-L-Pro in cyclic beta-hairpin cationic antimicrobial peptidomimetics,” Organic & Biomolecular Chemistry 5(19):3100-3105 (2007).
PCT/US10/43599 Search Report and Written Opinion mailed Apr. 28, 2011.
PCT/US10/43598 Search Report and Written Opinion mailed Apr. 20, 2011.
Torisu et al., “Discovery of new chemical leads for prostaglandin D2 receptor antagonists,” Bioorg. Med. Chem. Ltrs. 14:4557-4562 (2004).
PCT/US09/58655 Search Report and Written Opinion dated May 10, 2010.
Arima and Fukuda, “Prostaglandin D2 Receptors DP and CRTH2 in the Pathogenesis of Asthma,” Curr. Mol. Med. 8:365-375 (2008).
Hata and Breyer, “Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation,” Pharmacol. Ther. 103:147-166 (2004).
Kostenis and Ulven, “Emerging roles of DP and CRTH2 in allergic inflammation,” Trends Mol. Med. 12(4):148-158 (2006).
Medina and Liu, “PGD2 Antagonists,” Annual Reports Med. Chem. 41:221-235 (2006).
Pettipher et al., “Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases,” Nature Reviews/Drug Discovery 6:313-325 (2007).
Science IP Structure Search dated Jul. 8, 2008.
Science IP Structure Search dated Aug. 15, 2008.
Tirouvanziam et al., “Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways,” PNAS 105(11):4335-4339 (2008).
Ulven and Kostenis, “Targeting the Prostaglandin D2 Receptors DP and CRTH2 for Treatment of Inflammation,” Curr. Topics Med. Chem. 6:1427-1444 (2006).
GB 0916810.5 Search Report dated Dec. 10, 2009.
Crosignani et al., “Discovery of a new class of potent, selective, and orally bioavailable CRTH2(DP2) receptor antagonists for the treatment of allergic inflammatory diseases” J Med Chem 51:2227-2243 (2008).
Evans et al., “Seeing the future of bioactive lipid drug targets,” Nature Chem Biol 6:476-479 (2010).
Kim et al., “Regulation of Immune Cells by Eicosanoid Receptors,” TheScientificWorld Journal 7:1307-1328 (2007).
Ly and Bacon, “Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview,” Exp Opin Invest Drugs 14:769 (2005).
Pettipher et al., “The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses,” Br J Pharmacol 153:S191 (2008).
Pettipher et al., “Antagonists of the prostaglandin D2 receptor CRTH2,” Drug News Perspect 21:317-322 (2008).
Prieto et al., “Racemization in Suzuki couplings: a quantitative study using 4-hydroxyphenylglycine and tyrosine derivatives as probe molecules,” J Org Chem 72(3):1047-1049 (2007).
Sandham et al., “7-Azaindole-3-acetic acid derivatives: potent and selective CRTH2 receptor antagonists,” Bioorg Med Chem Lett 19:4794-4798 (2009).
Sandig et al., “Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function,” J Leukocyte Biology 81:372-382 (2007).
Scott et al., “Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis,” Bioorg Med Chem Ltrs (2011), doi: 10.1016fj.bmcl.2011.01.024.
Shrader et al., “Factor VIIa inhibitors: Gaining selectivity within the trypsin family,” Bioorg Med Chem Ltrs 16(6):1596-1600 (2006).
Stearns et al.,

Affiliated with

Also associated with

Rating

Heteroaryl antagonists of prostaglandin D 2 receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heteroaryl antagonists of prostaglandin D 2 receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroaryl antagonists of prostaglandin D 2 receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4277234