Hepatic stellate cell progenitors and methods of isolating same

Details Hepatic stellate cell progenitors and methods of isolating same Hepatic stellate cell progenitors and methods of isolating same

2007-05-24

2010-11-02

Ford, Allison M (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S378000, C435S370000

Reexamination Certificate

active

07824911

ABSTRACT:
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle α-actin, nestin, hepatocyte growth factor, stromal derived factor-1α and H1x homeobox transcriptional factor.

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