Heparin compositions freed of mineral salts, particularly oxalat

Details Heparin compositions freed of mineral salts, particularly oxalat Heparin compositions freed of mineral salts, particularly oxalat

1982-12-22

1987-03-24

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, A61K 31725, C08B 3710

Patent

active

046525556

ABSTRACT:
This invention relates to oxalate-free preparations of heparin, particularly in the form of calcium salts of heparin, which can be used for the preparation of injectable solutions of heparin which have long storage life.
The invention is also directed to a process for freeing heparin from its oxalate content, such as by fractional precipitations by alcohol in the presence of adjusted amounts of mineral salt, until the heparin precipitated contains less than about 70 ppm of oxalate but may contain less than about 30 ppm, preferably even less than 20 ppm.

REFERENCES:
patent: 3135660 (1964-06-01), Bush et al.
patent: 3482014 (1969-12-01), Koh
patent: 4168377 (1979-09-01), Choay et al.

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