Hemoglobins as drug delivery agents

Details Hemoglobins as drug delivery agents Hemoglobins as drug delivery agents

1995-06-01

1998-06-02

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

530385, 424 111, 424 165, 424 91, A61K 5100, A61M 3614

Patent

active

057595178

ABSTRACT:
A tracer, such as a radioisotope, is conjugated to a hemoglobin-like protein, such as normal hemoglobin, for use as an in vitro diagnostic imaging agent.

REFERENCES:
patent: 3934008 (1976-01-01), Rittel et al.
patent: 3980764 (1976-09-01), Adams
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4042677 (1977-08-01), Molinski et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4291013 (1981-09-01), Wahlig et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4321259 (1982-03-01), Nicolau et al.
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4338397 (1982-07-01), Gilbert et al.
patent: 4374932 (1983-02-01), Pitzele et al.
patent: 4377512 (1983-03-01), Ajisaka et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4473476 (1984-09-01), Scannon
patent: 4473563 (1984-09-01), Nicolau et al.
patent: 4474893 (1984-10-01), Reading
patent: 4497932 (1985-02-01), Trovati
patent: 4500507 (1985-02-01), Wong
patent: 4511503 (1985-04-01), Olson et al.
patent: 4512922 (1985-04-01), Jones et al.
patent: 4529719 (1985-07-01), Tye
patent: 4540564 (1985-09-01), Bodor
patent: 4551433 (1985-11-01), DeBoer
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4598064 (1986-07-01), Walder
patent: 4599197 (1986-07-01), Wetzel
patent: 4600531 (1986-07-01), Ivalder
patent: 4620948 (1986-11-01), Builder et al.
patent: 4650786 (1987-03-01), Wong
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4704692 (1987-11-01), Ladner
patent: 4710488 (1987-12-01), Wong
patent: 4730936 (1988-03-01), Thorjmsen, Jr.
patent: 4738952 (1988-04-01), Ecanow et al.
patent: 4769326 (1988-09-01), Ruter
patent: 4774180 (1988-09-01), Toth et al.
patent: 4777244 (1988-10-01), Bonhard et al.
patent: 4783529 (1988-11-01), Lavallee et al.
patent: 4839419 (1989-06-01), Kramer et al.
patent: 4840896 (1989-06-01), Reddy et al.
patent: 4842856 (1989-06-01), Hoederath et al.
patent: 4849142 (1989-07-01), Fujioka et al.
patent: 4868158 (1989-09-01), Masquelier et al.
patent: 4879272 (1989-11-01), Shimoda et al.
patent: 4918008 (1990-04-01), Gauri
patent: 4920194 (1990-04-01), Feller et al.
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5049493 (1991-09-01), Khosla et al.
patent: 5069936 (1991-12-01), Yen
patent: 5173426 (1992-12-01), Fischer et al.
patent: 5234903 (1993-08-01), Nho et al.
patent: 5250665 (1993-10-01), Kluger et al.
patent: 5545727 (1996-08-01), Hoffman et al.
patent: 5599907 (1997-02-01), Anderson et al.
Perutz et al (1986), J. Am. Chem. Soc, vol. 108, pp. 1064-1010, "Hemoglobin as a Receptor of Drugs and Peptides : X-ray Studies of the Stereochemistry of Binding".
Mathews et al (1989), J. Biol. Chem., vol. 264, No. 28, pp. 16573-16583, "The Effects of E7 and E11 Mutations on the Kinetics of Ligand Binding to R State Human Hemoglobin".
Taylor et al (1992), J. Nucl. Med., vol. 33, pp. 1836-1842, Technetium-99m-N1-(2-mercapto-2-methyl propyl)-N2-(2-proparcylthio-2-methyl-propyl)-1,2-benzene didmine (T.sub.691) : Preclinical Studies of a Potential New Tracer of Regional Cerebral Perfusion.
Nagai et al, "Refolding and Crystallographic Studies . . . " Biochem. Soc. Trans. 16 (2): 108-110, 1988.
Moens et al, "A Structural Domain of the Covalent Polymer Cali . . . " J. Biol. Chem. 263: 4679-4685, Apr. 5, 1988.
Shen, "Multiple joined genes prevent product degradation . . . E. coli", PNAS 81:4627-4631, Aug. 1984.
Schulz et al, "Increased Expression in E. coli of a Synthetic Gene " J. Bacteriology 169 (12): 5385-5392, Dec. 1987.
Liebhater et al., PNAS 77: 7054-7058, Dec. 1950.
Nagai et al., PNAS 82: 7252-7255, Nov. 1985.
Saito et al. J. Biochem. 101: 1281-1288, 1987.
Schoner, et al., PNAS 83: 8506-8510, Nov. 1986.
Springer et al., PNAS 84: 8961-8965, Dec. 1987.
Hallewell et al., J. Biol. Chem. 264: 5260-5268, Mar. 1989.
Guareute et al., PNAS 79: 7410-7414, Dec. 1982.
DeLaach et al, Am. J. Vel. Res., vol. 42, No. 4, pp. 667-669, Apr. 1981.
Chen et al, Journal of Controlled Release, vol. 8, pp. 93-101, 1988.
Willmott et al, Journal of Controlled Release, vol. 8, pp. 103-109, 1988.
Mathews et al, The Journal of Biological Chemistry, vol. 264, No. 28, pp. 16573-16583, Oct. 5, 1959.
Perutz et al., J. Am. Chem. Soc., vol. 108, pp. 1064-1078, 1986.
Peru et al, J. Am. Chem. Soc. 1078, 1986, vol. 108.
Abstract DBA Accession No. 89-12842 on Dialog File 357, of DeBaeteller, et al.; Yeast as a source of human lysozyme -synthetic gene cloning and expression in S. cerevisiae, Hedec. Fac. Landbouwet. Rijksuniv. Gent, 53:2135-41 (1988).
DeBoer et al.; Portable Shine-Delgarno Regions: A System for a Systematic Study of Defined Alterations of Nucleotide Sequences within E. coli Ribosome Binding Sites; DNA, 2:231-235 (1983).
DeGrado et al.; Protein Design, a Minimalist Approach Science 243:622 (1989).
Denefle et al.; Chemical synthesis of a gene coding for human angiogenin, its expression in E. coli and conversion of the product into its active form; Gene, 56:61-70 (1987).
DeVenuto, et al.; Appraisal of Hemoglobin Solution as a Blood Substitute Surgery, Gynecology and Obstetrics, 149:417-436 (1979).
Dickerson et al.; Evolution of the Oxygen Carriers Hemoglobin, Structure, Function, Evolution and Pathology; Chapter 3:66-115 (1983).
DiMarchi et al.; Chemical synthesis of human epidermal growth factor (EGF) and human type .alpha. transforming growth factor (TGF.alpha.); Peptides:Chemistry and Biology, 202-203 (1988).
Dowling et al.; A Clinical Study of Fluosol and Hyperbaric Oxygen as an Adjunct to Radiation Therapy Biomat. Art Cells and Immobil. Biotech. Abstract 19:377 (1991).
Ebert et al.; On the Introduction of Disulfide Crosslinks into Fibrous Proteins and Bovine Serum Albumin Adv. Exp. Med. Biol. 86A:235-245 (1977).
Edens et al.; Synthesis and Processing of the Plant Protein Thaumatin in Yeast Cell, 37:629-633 (1984).
Ernst, J.F.; Improved Secretion of Heterologus Proteins by S. cerevisiae: Effects of Promoter Substitution in Alpha-Factor Fusions; DNA 5(6):483-491 (1986).
Feola et al.; Nnephrotoxicity of Hemoglobin Solutions Biomat. Art. Cells Art. Org. 18(2)233-249 (1990).
Fermi et al.; The Crystal Structure of Human Deoxyhaemoglobin at 1-74 A Resolution J. Mol. Biol.; 175:159-174 (1984).
Freedman et al.; Formation of Disulphide bonds Biological Laboratory, University of Kend, Canterbury, U.K.; 158-212 (1980).
Fronticelli et al.; Bovine hemoglobin pseudo-crosslinked with mono( 3,5-dibromosalicyl)-fumarate Eur. J. Biochem. 192:331-336 (1990).
Fushitani et al.; The Amino Acid Sequences of Chains a, b, and c That Form the Trimer Subunit of the Extracellular Hemoglobin from Lumbricus terrestris; J. Biol. Chem.; 263(14):6502-6517 (1988).
Fushitani et al.; The Extracellular Hemoglobin of the Earthworm, lumbnicus terrestrisJ. Biol. Chem.; 266(16):10275-10251 (1991).
Gatenby et al.; Co-expression of both the maize large and wheat small subunit genes ribulose-biphosphate carboxylase in E. coli; Eur. J. Biochem; 168:227-231 (1987).
Giatini et al.; Reovirus major capsid protein expressed in Escherichia coli Gene, 56:153-160 (1987). Cro repressor of bacteriophage lambda FEBS Lett., 289(2):201-204 (1991).
Goossens, et al.; Triplicate alpha globin loci in humans: PNAS, 77(1):518-521 (1980).
Gottesman et al.; Transcription Antitermination by Bacteriophage Lambda N Gene Product J. Mol. Biol. 140:57-75 (1980).
Gould et al.; The Development of Polymerized Pyridoxylated Hemoglobin Solution as a Red Cell Structure Ann. Emerg. Med., 15:1416-1419 (1986).
Greaves et al.; A transgenic mouse model of sickle cell disorder Nature, 343:183-185 (1990).
Greer et al.; Three Dimensional Structure of Hemoglobin Rainier Nature New Biology, 230:261-264 (1971).
Guthrie et al.; The Molecular Biology of the Yeast Sacharomyces 487-528 (Cold Spring Harbor Laboratory; 1988).
Haase-Pettingell and King; Formation of Aggregates from a Thermolabile in vivo Folding Intermediate in P22 Talispike Maturation; J. Biol. Chem., 263:4977-83 (1988).
Hallewell et al.; Amino Terminal Acetylation of Authentic Human CuZn Superoxide Dismutase Produced in Yeast Biotechnology, 5:363-366

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