Helix mimetics and composition and methods related thereto

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S249000, C544S145000, C544S350000

Reexamination Certificate

active

07405212

ABSTRACT:
Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure:including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, R1and R2are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening such libraries to identify biologically active members.

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patent: 5446128 (1995-08-01), Kahn et al.
patent: 5710245 (1998-01-01), Kahn et al.
patent: 5840833 (1998-11-01), Kahn et al.
patent: 5859184 (1999-01-01), Kahn et al.
patent: 1130022 (2001-09-01), None
Cook et al. (Chemistry of Penicillin (H. T. Clarke, et al.) (Princeton Univ. Press) (1949) 921-72). Abstract.
Hodgson et al. (Journal of the American Chemical Society (1954), 76, 1137-40). Abstract.
Khokhlov et al. (Khimiya Geterotsiklicheskikh Soedinenii (1971), 7(3), 309-15). Abstract.

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